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News Will up-titration or combination with bisoprolol help to better control hypertension in amlodipine users?

Will patients with hypertension who do not achieve control of this condition with amlodipine at a dose of 5 mg benefit more from up-titration or combining it with bisoprolol? The answer to this question was sought in a study published this year by German authors.

Source: Cardiovascular Continuum 25. 10. 2022

News Pharmacological Profile of Mavacamten and Key Studies of Its Use in HCM Treatment

A new addition to the treatment options for hypertrophic cardiomyopathy, approved for use in European Union countries in June 2023, is the selective reversible cardiac myosin inhibitor mavacamten. The following review summarizes its fundamental pharmacological characteristics along with the results of several crucial clinical studies and highlights the potential integration of mavacamten into clinical practice.

Source: Hypertrophic Cardiomyopathy (HCM) 1. 11. 2023

Články časopisu Immunotherapy in the Treatment of Lung Cancer

Author of the article: O. Fiala, O. Šorejs, M. Pešek, J. Fínek Source: Klinická onkologie | Supplementum3/2017 12. 12. 2017

News Critical Conditions in Obstetrics 2022: What is Available in the Czech Republic for Managing Peripartum Life-Threatening Bleeding?

On December 10, 2022, a professional meeting entitled Critical Conditions in Obstetrics 2022 was held in the lecture hall of the new building of the National Museum in Prague. Prof. MUDr. Antonín Pařízek, CSc., from the Department of Gynecology and Obstetrics of the 1st Faculty of Medicine, Charles University, and General University Hospital in Prague, gave a presentation addressing the issue of peripartum life-threatening bleeding (PLTB), the necessities for its management, and provided an overall perspective on the current situation in obstetrics in our country.

Source: Postpartum Hemorrhage 14. 3. 2023

News Does olaparib improve overall survival in patients with recurrent ovarian cancer and BRCA mutation?

Olaparib, a poly(ADP-ribose) polymerase (PARP) enzyme inhibitor, in tablet form is indicated, among other things, for the maintenance treatment of adult patients with platinum-sensitive recurrent high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who respond (complete or partial response) to platinum-based chemotherapy. Its efficacy in this indication in terms of prolonging progression-free survival and overall survival was addressed by the phase III study presented below.

Source: Ovarian and Breast Cancer 13. 2. 2021

News Maintenance Therapy After Oxaliplatin Discontinuation Based on Panitumumab

Panitumumab is an approved therapy for metastatic colorectal cancer without RAS oncogene mutation (wtRAS mCRC) and has been evaluated for 1st-line treatment through randomized phase II (PEAK) and III (PRIME) studies. A retrospective analysis of these studies assessed the efficacy and safety of panitumumab as the basis for therapy in these patients after discontinuation/termination of oxaliplatin.

Source: Colorectal Cancer 20. 2. 2020

News Natural Doesn’t Always Mean Better –⁠ How to Deal with the Appeal to Nature in the Doctor’s Office

"Herbs rather than chemicals." Doctors are hearing similar statements more and more often. This attitude reflects the so-called appeal to nature –⁠ a logical fallacy based on the assumption that natural means better and safer. In academic literature, this type of thinking is more broadly referred to as the naturalistic fallacy. Such reasoning significantly influences not only patients’ decisions but often also those of healthcare professionals themselves.

Source: 11. 8. 2025

Články časopisu Enteral nutrition in the treatment of inflammatory bowel disease

Author of the article: J. Schwarz, J. Sýkora, D. Cvalínová Source: Česko-slovenská pediatrie | 5/2017 9. 10. 2017

News Reduction of Inflammation in Vertebral Bodies and Posterolateral Structures of the Spine in Patients with Ankylosing Spondylitis Treated with Tofacitinib

A post hoc analysis of a phase II study with tofacitinib in patients with active ankylosing spondylitis (AS) evaluated the suppression of spinal inflammation using magnetic resonance imaging (MRI) based on the Canadian-Danish scoring system (CANDEN), which allows for the assessment of changes in posterolateral structures of the spine, characteristic of AS involvement.

Source: Arthritis 23. 11. 2023

News Importance of Testing for Iron Deficiency in Patients with Chronic Heart Failure and Treatment Options

Intravenous iron application in patients with heart failure and iron deficiency is now part of ESC guidelines aimed at improving symptoms, increasing exercise tolerance and quality of life in these patients, and simultaneously reducing the risk of hospitalization or death from cardiovascular causes.

Source: Iron Deficiency and Anemia 5. 10. 2021

News Picking from the Red Book of the CHS: What's New in This Year's Recommendations for Diagnosis and Treatment of AML?

In recent years, there have been significant advances in the diagnosis and therapy of acute myeloid leukemia (AML). High-quality laboratory diagnostics (molecular genetics, cytogenetics, and flow cytometry) are absolutely essential, and monitoring measurable residual disease is becoming increasingly important. The range of treatment options is also beginning to expand. The content of the latest 'Recommendations for the Diagnosis and Treatment of Acute Myeloid Leukemia (AML),' which are part of this year's updated 'Red Book' of the Czech Hematology Society ČLS JEP (CHS), is primarily based on the 2022 European Leukemia Network (ELN) guidelines and offers, among other things, an updated disease classification and risk stratification, as well as an overview of current treatment options for both intensive and non-intensive regimens.

Source: Acute Myeloid Leukemia 29. 11. 2023

News Diagnosis, Treatment, and Outcomes Achieved in Patients with Non-Small-Cell Lung Cancer in Central Europe

In June 2020, the journal Radiology and Oncology published the results of an analysis of data from patients with stage III non-small-cell lung cancer (NSCLC) from a Central European registry. A large team led by Czech experts focused on the diagnostic and therapeutic procedures used and the treatment results achieved in real-world practice.

Source: Lung Cancer 6. 1. 2021

News Can the use of sartans reduce mortality and severity of COVID-19 in hypertensives?

Existing scientific and clinical evidence suggests the involvement of the renin-angiotensin-aldosterone system (RAAS) in the pathophysiology of COVID-19. Some of the initial experimental therapy proposals included various interventions in the RAAS.

Source: Sartans in the Treatment of Hypertension 21. 7. 2022

News Immunotherapy of Cancer Diseases

Immunotherapeutic strategies have been successfully utilized recently in the treatment of various malignancies. Increasing understanding of the interactions between the tumor and the host organism over the last few years has led to proposals of various promising therapeutic approaches. This overview briefly summarizes the basic principles of immunotherapy for cancer diseases.

Source: Immunotherapy in Oncology 1. 10. 2020

News Diagnosis of AAT Deficiency According to Italian Recommendations and a Clear Algorithm for Practice

Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that primarily affects the lungs and liver. It is considered a rare disease, but it is also significantly underdiagnosed. Given the availability of specific treatment, which involves the administration of purified alpha-1 antitrypsin (AAT) derived from human plasma in patients with COPD due to AATD, identifying these patients is crucial. We summarize the recently issued Italian recommendations for the diagnosis of AATD and place them in the context of Czech standards.

Source: Deficiency of Alpha-1-Antitrypsin 1. 11. 2022