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News Benefits of Time-Limited CLL Therapy

The advent of new targeted molecules has significantly influenced the possibilities of therapy for chronic lymphocytic leukemia (CLL) and are now an integral part of treatment regimens, including the 1st line. Individual therapeutic approaches and strategies based on them have their advantages and disadvantages as well as their target patient group, but the concept of time-limited treatment is increasingly gaining ground. Therapy today is significantly individualized, and its optimal choice is based on the assessment of various circumstances on the patient’s part and their disease.

Source: Chronic Lymphocytic Leukemia 5. 3. 2024

News Telmisartan, amlodipine, and chlorthalidone in a low-dose fixed triple combination –⁠ better control of target blood pressure values?

The secondary analysis of the TRIUMPH study, recently published in JAMA Cardiology, is likely the first published assessment of time spent in the target blood pressure (BP) range during antihypertensive treatment. This parameter was assessed in patients with moderate hypertension using a low-dose triple combination of antihypertensives (telmisartan 20 mg, amlodipine 2.5 mg, and chlorthalidone 12.5 mg) compared to usual care.

Source: Sartans in the Treatment of Hypertension 15. 6. 2022

News Safety and Tolerability of Bilastine in the Treatment of Chronic Urticaria in Children

Chronic urticaria is less common in pediatric patients compared to the acute form, but it always requires therapy due to bothersome chronic symptoms that reduce quality of life and disrupt daily activities of affected children. According to recent guidelines, the first-line treatment is non-sedating second-generation antihistamines, among which bilastine is included.

Source: Allergic Reactions 17. 8. 2020

News Hydrotherapy in the Treatment of Non-Healing Wounds

For the treatment of wounds, it is crucial how they are managed during the cleaning and granulation phases. For most non-healing wounds, so-called Hydrotherapy (treatment with hydroresponsive dressings) is suitable, which involves just two steps. The essence of Hydrotherapy is the maintenance of a moist environment and, if possible, a constant temperature in the wound.

Source: Wound Healing 10. 2. 2021

News Thyroid Disorder Screening in Pregnancy to Be Tested by Pilot Program Starting September

The expectations surrounding the trial launch of the screening program were discussed by Professor Michal Kršek, Chairman of the Czech Endocrinological Society ČLS JEP, on the occasion of the 12th annual “Thyroid Week”.

Source: Thyroid Disorders 8. 6. 2020

News Concise and Practical Recommendations for Optimal Care of Dental Prostheses

Millions of people around the world use full or partial dental prostheses. However, there are no standardized global procedures with guidelines on how to care for dental prostheses. Dentists and professional organizations, however, agree on one thing –⁠ the prosthesis must be cleaned regularly. The following practical recommendations are based on existing evidence and clinical studies that outline the best practices for cleaning dental prostheses.

Source: Optimal Care of Dentures 4. 5. 2020

News Myths Accompanying Therapy of Arterial Hypertension

Arterial hypertension is among the most common yet most underestimated diseases in the adult population. Misinterpretation of data and inadequate management of this disease can be caused, among other things, by an excessive amount of available clinical data and its incorrect analysis. Insufficient control of blood pressure (BP) is, however, one of the most significant factors in increased cardiovascular (CV) mortality.

Source: ACE inhibitory 18. 4. 2021

News What is the effectiveness of levodropropizine in the treatment of children's cough?

Levodropropizine represents an effective and safe option for the treatment of acute irritating cough in children. How does it compare to dropropizine and commonly used centrally acting antitussives?

Source: Cough Therapy 15. 2. 2022

News Forgotten Pulmonologists: COVID-19 Detection in Patients with Lung Disease

The Czech Pneumological and Phthisiological Society of ČLS JEP (ČPFS) submitted a request to the Ministry of Health of the Czech Republic on March 25, 2020, to allow pulmonologists to send patients with suspected COVID-19 directly for infection testing. In their statement, they also provide recommendations on how to manage care for patients with chronic lung diseases during the outbreak of the SARS-CoV-2 virus and how these patients should behave.

Source: Asthma under control 7. 4. 2020

News Neuraxpharm Introduces a New Form of Medical Cannabis

Since November 2022, a new medication containing an active full-spectrum cannabis extract –⁠ Naxiva Panaxol from Neuraxpharm –⁠ has been available in the Czech Republic. The cannabis extract is offered in collaboration with Panaxia Labs Israel. Both companies are key players in the European medical cannabis market. Their agreement ensures the distribution of these products not only in the Czech Republic but also in Switzerland and Germany.

Source: Medical Cannabis 16. 3. 2023

News Less Ventricular Arrhythmias and ICD Shocks After Introduction of Sacubitril/Valsartan

Is the decrease in the incidence of sudden cardiac death among patients using sacubitril/valsartan due to a lower risk of ventricular arrhythmias? And does it have anything to do with reverse left ventricular remodeling? A newly published study utilizing data from telemonitoring of patients with implanted devices focused on this.

Source: Chronic Heart Failure and Lipidology 8. 1. 2020

News LDL cholesterol: a new risk factor for the onset of venous thromboembolic disease?

Not only do atherosclerotic plaques in the arteries and the risk of heart attack decrease along with LDL cholesterol levels. Results from a large molecular genetic study suggest that lowering its levels might also reduce the risk of venous thromboembolic disease.

Source: Cardiovascular Risks 3. 2. 2020

News Relationship Between Mortality and Use of Statins or RAAS Inhibitors After Aortic Valve Replacement

The impact of prescribed medication after transcatheter aortic valve replacement (TAVR) has not been precisely assessed to date. A recently published retrospective analysis of clinical practice data from patients who underwent TAVR aimed to assess the potential benefit of using statins and renin-angiotensin-aldosterone system (RAAS) inhibitors.

Source: Sartans in the Treatment of Hypertension 16. 3. 2023

News Genetic Profiling Transforms the Diagnosis and Treatment of Cancer Diseases

Genome sequencing provides doctors with more information about the causes of cancer diseases and changes the ways of treating tumors. Targeted therapy aimed at oncogenic mutations has brought patients longer survival and better clinical outcomes. Let's take a closer look at the advances and challenges of using genomics in oncology.

Source: Genetic Profile and Treatment of NSCLC 11. 11. 2021

News Osimertinib in the Treatment of Patients with NSCLC with Secondary EGFR T790M Mutation –⁠ Case Study

Non-small cell lung cancer (NSCLC) is a genetically heterogeneous disease. Individualization of therapy based on the presence of specific tumor cell mutations is therefore crucial for choosing the optimal therapy for these patients. One of the targeted treatment options for patients with NSCLC with an activating mutation in the epidermal growth factor receptor (EGFR) gene is osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR TKI). We present a case study of a patient with NSCLC treated with osimertinib after disease progression due to a secondary EGFR T790M mutation resulting from afatinib therapy. The described case well illustrates the role of osimertinib in the treatment of NSCLC with secondary EGFR T790M mutation.

Source: Lung Cancer 10. 6. 2020