Search results: (10000)
News Incontinence Dermatitis - Common, Yet Often Overlooked Diagnosis
Incontinence dermatitis is an inflammatory skin reaction with a prevalence between 3 and 25%, caused by prolonged skin contact with urine or feces. It is classified among contact irritant dermatitis. It causes significant discomfort to patients and can also require difficult and prolonged treatment.
News Comparison of Clinical Outcomes of TKA Implantation: ATTUNE vs. SIGMA
The ATTUNE total knee arthroplasty (TKA) system was introduced to the market in 2013 as a successor to the popular SIGMA system. The new type of knee endoprosthesis is designed to provide better stability and mobility than the previous implant. Several studies have evaluated the clinical outcomes of the implantation of both types of endoprostheses.
News Morning Myopic Shift and Glare in Patients with Advanced Fuchs Endothelial Corneal Dystrophy
A newly published study by a German team analyzes the morning and afternoon differences in various parameters in patients with Fuchs endothelial corneal dystrophy to determine which of them contribute to subjective visual difficulties in the morning.
News Effectiveness of Bisoprolol in Patients with Cardiac Arrhythmias – A Systematic Review of Studies
Last year, a Franco-Romanian team published a study that conducted a systematic review of existing evidence on bisoprolol in the context of arrhythmia treatment. The authors noted that bisoprolol, like other beta-blockers (BB), is used for a variety of cardiovascular diseases, but it is not mentioned in the European Society of Cardiology (ESC) guidelines for managing patients with ventricular arrhythmias and preventing sudden cardiac death.
News Liposomal Ozonated Oil in the Treatment of Eye Infections
Liposomal ozonated oil is a new ocular antiseptic with antibacterial, anti-inflammatory, and regenerative properties, making it suitable for the prevention and treatment of eye infections and as an adjuvant in wound healing. In June 2022, Spanish authors published a review summarizing findings on the mechanism of action and results of preclinical and clinical studies with ozonated oil in the treatment of eye infections and in the regeneration of the ocular surface. It also highlights the benefits of ozonated oil compared to conventional antiseptics such as povidone-iodine and chlorhexidine.
News Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?
Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of tiapridal and carbamazepine in the treatment of AWS. Is this combination a viable alternative to benzodiazepines or clomethiazole?
News Most Common Dermatoses Around the Stoma
The incidence of stomal complications ranges between 20 and 70%. One type of complication is dermatoses affecting the peristomal skin. These issues can occur in the early postoperative period, but also several years later.
News Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum – Interactive Case Study
In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you would proceed in diagnosing and treating this case.
News Treatment for Transthyretin Cardiac Amyloidosis is Now More Accessible to Czech Patients
Transthyretin cardiac amyloidosis is a serious progressive disease that was until recently considered untreatable. In recent years, however, new treatment options targeting the underlying pathology of the disease have emerged, which, along with advances in non-invasive diagnostics, offer patients hope for a longer and better-quality life.
News Omalizumab and Treatment of Severe Refractory Asthma in Pregnant Women
Omalizumab is commonly recommended for the treatment of severe refractory asthma. A special group of patients are pregnant women with asthma, for whom the risks of inadequately treated asthma must be weighed against the risks of biological treatment for the fetus. EXPECT is a pregnancy registry that has served since 2006 as a prospective observational study; its aim is to collect data on women treated with omalizumab during pregnancy and compare it with data from asthmatic women who did not receive omalizumab.
News Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin
Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be expected to alleviate painful symptoms and improve sleep quality, thereby significantly enhancing patients' quality of life.
News 10 Properties and Benefits of Gliptins: How They Work and When to Prescribe Them
General practitioners can now prescribe oral antidiabetics from the group of gliptins to patients with type 2 diabetes. Their therapeutic options are significantly expanded in the care of these patients. In the following text, we briefly summarize the mechanism of action of gliptins and their advantages over other oral antidiabetics.
News Epilepsy with Generalized Tonic-Clonic Seizures in an Adolescent Patient – A Case Study
This is the story of Anička, a 16-year-old girl who has been treated for epilepsy since she was 14. Her condition is accompanied by generalized tonic-clonic seizures, which may need to be managed acutely with rescue medication, either at home or at school. Instead of the previously used rectally administered diazepam, a new, safer and more comfortable option for rescue medication is now available: buccally administered midazolam. This modality may also help alleviate anxiety and other psychological impacts related to the condition, as illustrated by our case study.
News Memantine Eases Daily Life for Patients and Caregivers
What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?
News At the Crossroads: 5 Options for Alzheimer's Disease Pharmacotherapy
Currently, we have 5 basic options for the pharmacotherapy of Alzheimer's disease. Is memantine, one of the three cholinesterase inhibitors, or combination therapy the most effective? A review article by Japanese and American authors evaluates the literature on the safety and efficacy of cognitive treatments for Alzheimer's disease.
News Pediatric Immune Thrombocytopenia Does Not Overlap with Adult ITP
Immune thrombocytopenia (ITP) is a highly heterogeneous disease characterized by various bleeding manifestations and different needs for treatment or likelihood of remission. The difference is accentuated in terms of the disease course between children and adult patients.
News Current European Recommendations for the Treatment of Renal Colic Due to Urolithiasis
At the annual congress in Milan in 2023, new recommendations from the European Association of Urology (EAU) for the acute treatment of patients with renal colic were presented. We summarize the key points concerning primarily analgesic treatment.
News Doc. Debora Karetová: Do Not Underestimate the Complexity of CHVO Treatment and Early Stages of the Disease
Are you applying the optimal approach to the treatment of chronic venous disease? What do the new Czech recommendations bring? And what is the current role of venopharmacs in treatment management? You can read all about this in an interview with the chair of the Czech Angiological Society ČLS JEP Doc. MUDr. Debora Karetová, CSc., from the 2nd Internal Clinic – Clinic of Cardiology and Angiology at the 1st Faculty of Medicine, Charles University, and General University Hospital in Prague.
News Alzheimer's Disease: Diagnosis Step by Step in 4 Points
Alzheimer's disease is the most common cause of dementia. With the aging population, this topic is becoming increasingly relevant. How have the knowledge and diagnostic possibilities of the disease progressed over the past decades?
News Analysis of the Benefits of Combining Enalapril/Bisoprolol in Patients with Acute MI
A recently published retrospective analysis compared the outcomes achieved by administering enalapril alone and in combination with bisoprolol in patients after acute myocardial infarction over a period of 1 year.
News Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension
Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of cognitive dysfunction. According to available data, metformin may reduce the risk of developing frailty in postmenopausal women. A recently published Italian study, LEOPARDESS, aimed to evaluate the effect of extended-release metformin on the cognitive functions of this population of women.
News Comparison of 5 Beta-Blockers in Heart Failure with Reduced Ejection Fraction
An analysis of 26 studies with beta-blockers in the treatment of heart failure with reduced ejection fraction compared 5 drugs (bisoprolol, metoprolol-succinate, metoprolol-tartrate, carvedilol, and nebivolol). The results showed a more favorable prognosis with bisoprolol compared to carvedilol, a similar effect on prognosis for carvedilol, metoprolol-succinate, and nebivolol, and the least favorable prognosis with metoprolol-tartrate.
News Memantine, Acetylcholinesterase Inhibitors, and Their Combination in the Treatment of Alzheimer's Disease − Findings from Meta-Analyses
Is memantine, an acetylcholinesterase inhibitor (donepezil), or their combination more advantageous in the therapy of Alzheimer's disease? Two meta-analyses tried to answer this question, and we summarize their conclusions in the following article.