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News Genetic Testing in Clinical Practice – An Irreplaceable Tool in Prevention, Diagnosis and Treatment
Genetic testing has long ceased to be the privilege of clinical research. In practice, it is commonly used for screening, diagnosis, and prognosis determination in diseases with an evident genetic component, and subsequently for tailoring pharmacotherapy to the individual patient. The richest experience with genetic testing belongs to reproductive medicine and the field of prenatal diagnostics, as well as pediatrics associated with rare disease medicine and oncology. Today, the significance of testing is becoming apparent in internal medicine and psychiatry as well.
News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia
The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.
News How Does Artificial Intelligence Help in Drug Development?
In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer the development of new drugs?
News Can the Use of Statins Help Reduce the Risk of Dementia?
A meta-analysis published last year by Taiwanese experts evaluated the connection between the use of statins and the incidence of dementia. What conclusions did the authors reach?
News Pitfalls of Levothyroxine Replacement Therapy
Hypothyroidism (reduced function of the thyroid gland) affects approximately 1-2% of the population. Its prevalence increases with age and it is more common in women. Synthetic thyroid hormone levothyroxine is used to treat hypothyroidism. It is a widely prescribed medication available in tablets of various strengths.
News Cardiovascular Risks in Schizophrenics: What Are They Related To and How To Eliminate Them?
Schizophrenia affects about 1% of the population. This disease is associated, among other things, with increased cardiovascular (CV) morbidity and mortality. What is the cause and what to focus on in primary prevention?
News Trazodone in the Treatment of Depressive Disorder – A Case Study
Presented by MUDr. Sylva Racková, Ph.D.
Psychiatric Clinic, Plzeň
News Alarming Data on Prevalence and Insufficient Treatment of Hypertension in Working Age − Another Underestimated 'Civilization Epidemic'?
The National Cardiology Information System (NKIS), developed by the Czech Society of Cardiology in collaboration with the Institute of Health Information and Statistics (ÚZIS), has provided the first data on the prevalence of hypertension in the Czech population. It revealed that even the treatment of a significant risk factor for cardiovascular diseases – hypertension – is not well managed in the Czech Republic. About 40% of patients with hypertension do not have regular preventive check-ups with their general practitioner, while 40% of hypertensive patients are simultaneously of working age.
News Genuair®/Pressair® Inhaler in the Treatment of COPD – Minimum Errors During Inhalation and High Patient Satisfaction
The article by German authors summarizes the results achieved with the Genuair® inhaler (marketed in the USA under the name Pressair®), highlighting its ease of use, simple patient training, low error rates during inhalation compared to other inhalers, and high patient satisfaction and willingness to continue treatment.
News Dabigatran vs. Warfarin: What and Why Do Patients Prefer?
The key to adherence to long-term anticoagulant therapy is primarily the satisfaction of patients with the set therapy. The RE-SONANCE study published in April 2021 compared patient satisfaction with anticoagulant treatment using the direct oral anticoagulant (DOAC) dabigatran versus vitamin K antagonists (VKAs). What were the findings?
News What situations can arise in PBC treatment with obeticholic acid? Answers provided by case studies from real practice at CKTCH
The Hradec Gastroenterology Days 2023 were traditionally held in March at the Educational Center of the Faculty of Medicine, Charles University, in the area of University Hospital Hradec Králové. The expert program included a lecture by MUDr. Libuše Husová, Ph.D., from the Cardio-surgical and Transplant Surgery Center Brno (CKTCH), who highlighted various situations that can arise during the treatment of primary biliary cholangitis (PBC) with three case studies.
News Characteristics of Chronic Wounds Related to Itching During Healing
Itching of wounds during healing is associated with larger wound size, more extensive tissue swelling, and the presence of granulation and necrotic tissue at the base. This was shown by an observational descriptive American study with 200 patients.
News Prof. Hana Rosolová: According to recent studies, caution is needed with beta-blockers only in severe cases of asthma and COPD
Beta-blockers (BB) are among the most widely used drug groups in cardiology. While their position is clear in some indications, it is debated in others. Additionally, individual BBs differ in various aspects, which plays an important role in selecting the right treatment for a particular patient. We discussed some current topics related to beta-blockers with the head physician of the Center for Preventive Cardiology of the 2nd Department of Internal Medicine LF UK and FN Plzeň Prof. MUDr. Hana Rosolová, DrSc., FESC.
News Newer Beta Blockers Offered for Use in Atherosclerosis Prevention
An article highlighting recent scientific findings on the beneficial effects of beta-blockers (BB) directly on the arterial wall and the potential benefit for the prevention of atherosclerotic cardiovascular disease (ASCVD) by adding BB to already established strategies for treating dyslipidemia and diabetes was published this year in the journal Current Atherosclerosis Reports.
News Effect of Zolpidem on the Quality of Overnight Sleep in Terms of Episodic Memory Formation
Zolpidem is a non-benzodiazepine hypnotic used for the short-term treatment of insomnia in adults. Previous studies have shown that this gamma-aminobutyric acid (GABA-A) agonist stimulates the occurrence of sleep spindles during short daytime sleep, thereby enhancing episodic memory. A recently published study focused on the effect of zolpidem on memory after overnight sleep.
News Treatment with Dupilumab in Severe Corticosteroid-Dependent Bronchial Asthma – A Case Study
We present the case of a 36-year-old woman with severe corticosteroid-dependent asthma with numerous comorbidities and complications due to long-term systemic corticosteroid therapy. Significant improvements in quality of life, asthma control, regression of skin changes in atopic dermatitis, and reduction in methylprednisolone consumption for this patient were only achieved after the initiation of biological treatment. Dupilumab, a monoclonal antibody against the α subunit of the receptor for interleukins IL-4 and IL-13, which is approved for the treatment of severe refractory eosinophilic bronchial asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyposis, was indicated in her treatment.
News Dupilumab – The First Biologic Umbrellaing Type 2 Inflammation Treatment: How Does It Work and Who Is It For?
A new drug is entering the market for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps – the biologic product Dupixent®. The active ingredient is dupilumab, a fully human monoclonal antibody administered subcutaneously using a pre-filled syringe.
News Proton radiotherapy means lower risk with high efficacy of radiation. The key is getting the patient into the treatment process as soon as possible
The Proton Therapy Center in Prague (PTC − Proton Therapy Center Czech) is a modern healthcare facility specializing in the treatment of oncological diseases using so-called proton radiotherapy. This therapy is covered by public health insurance in indicated cases. Since its opening in 2012, PTC has treated nearly 10,000 patients, not only from the Czech Republic and Slovakia. In 2019, it became part of the National Oncology Center.
News Weight-Based Enoxaparin Dosing vs. Standard Dosing in Trauma Patients
Thromboembolic disease is a common comorbidity in adult trauma patients, thus making routine thromboprophylaxis appropriate for these patients, most often in the form of low-molecular-weight heparins (LMWH). Standard thromboprophylaxis dosing regimens, however, are often associated with insufficient anti-Xa activity levels. A recently published clinical study by researchers from New York University focused on comparing the standard thromboprophylaxis regimen of enoxaparin with a weight-based dosing regimen in adult trauma patients.
News Targeted Treatment and Quality of Life in Patients with Follicular Lymphoma
The GALLIUM clinical trial evaluated chemotherapy in combination with targeted treatment using rituximab or obinutuzumab in previously untreated patients with advanced follicular lymphoma (FL). A secondary aim of the study was to assess the health-related quality of life. The results of the analysis were recently published in the journal Annals of Hematology.
News Carpal Tunnel Syndrome as a Warning Sign of Cardiomyopathy Caused by Transthyretin Amyloidosis
Recent study results suggest that transthyretin amyloidosis is a more common cause of heart failure than previously thought. Early diagnosis and subsequent therapy are key to improving patient prognosis. A comprehensive study evaluating data from the Danish population registry suggests that carpal tunnel syndrome may be one of the initial symptoms of the disease.
News A Look at Tongue and Its Care from the Perspective of Western and Traditional Chinese Medicine
The tongue is a valuable diagnostic tool used in both Traditional Chinese Medicine (TCM) and Western medicine. While the approaches to tongue care between these two medical systems differ significantly, both recognize the tongue's ability to reflect an individual's overall health. Although these approaches may seem contradictory, with proper application, they can complement each other.
News Under the Microscope: How is Patient Care for Heart Failure in the Czech Republic in Real Practice?
The journal Vnitřní lékařství recently published the results of a survey conducted among outpatient cardiologists and internists. The aim was to determine the level of diagnosis and treatment of patients with chronic heart failure (CHF) in real-life practice in the Czech Republic, with a special focus on the presence of symptoms in patients who have not yet been diagnosed. We briefly summarize the key findings from this survey.