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News Results of Knee and Hip Joint Arthroplasty in Hemophiliacs

Total endoprosthesis implantation represents an effective solution for the terminal stages of joint degeneration in hemophiliacs. However, compared to the general population, this group of patients exhibits certain specificities, a higher rate of complications, and historically worse surgical outcomes. Recent studies show that with advancements in surgical techniques, implants, and perioperative care, the results are approaching those of the population without a history of bleeding disorders.

Source: Hemophilia with Movement 15. 3. 2022

News How to Set Individual Treatment Goals for Type 2 Diabetes?

Treatment goals for type 2 diabetes should always be set individually. In practice, this mainly involves an indicator of the success of long-term compensation –⁠ glycated hemoglobin (HbA_1c). Recommendations for the diagnosis and treatment of diabetes for general practitioners from 2020 list different target HbA_1c values according to the risk of hypoglycemia and other parameters. They also recall different target values for fit, frail, and dependent seniors.

Source: Diabetes 28. 8. 2020

News Cardiovascular System Affection in Children with Noonan Syndrome

Noonan syndrome is a genetically conditioned disease classified among the so-called RASopathies, caused by a germline mutation in the genes of the RAS/MAPK signaling pathway. Among other things, children with this disease typically present with cardiovascular system involvement.

Source: Growth Disorders 13. 12. 2021

News Recommendations for Lipid Administration in Patients on Home Parenteral Therapy

Home parenteral therapy is an important part of treatment for patients with chronic intestinal failure who cannot achieve adequate nutrition through enteral feeding. An integral component of this therapy is lipid emulsion, which provides a source of energy and essential fatty acids. However, long-term administration of lipid emulsion may be associated with liver damage. According to available studies, the risk can be reduced by adjusting the dosage of lipid emulsion and preferring emulsions without soybean oil.

Source: Parenteral Nutrition 4. 10. 2021

News DPP4 Inhibitors in Chronic Kidney Disease and Their Potential to Protect Against Diabetic Nephropathy

Preclinical and clinical observations suggest that dipeptidyl peptidase 4 (DPP4) inhibitors might offer additional benefits to patients apart from effective and safe glycemic control.

Source: Diabetes 14. 12. 2020

News Clinical Benefit of Mucolytics in the Treatment of Upper Respiratory Tract Infections

A new review based on published controlled and observational studies as well as real-world practice experiences demonstrates the benefits of ambroxol, bromhexine, carbocisteine, erdosteine, N-acetylcysteine, and sobrerol in the treatment of upper respiratory tract infections, including bronchitis, sinusitis, and rhinosinusitis.

Source: Cough Therapy 6. 2. 2020

News MUDr. Petr Majtan: Venofarmaka should receive at least partial coverage for hemorrhoidal disease −⁠ their benefit in this indication is clear

What is the use of venofarmaka before and after surgery for chronic venous disease (CVD), and what effects of this treatment does he observe in daily practice with his patients? We asked MUDr. Petr Majtan from the private surgical and proctological clinic DK Chirurgie in Prague 10.

Source: Venous Insufficiency 17. 12. 2023

News Bite-Sized Pieces from EHA 2021: Two New Findings on T-Cell Lymphoma

Can a molecule that is crucial for the sensitivity of adult T-cell lymphoma or leukemia (ATLL) to NK cell cytotoxicity be identified? And what conclusions were drawn from the testing of an antibody specific for TRBC1 in the investigation of T-lymphoproliferative disorders? These topics were also covered at the EHA 2021 congress, in the electronic poster presentation section.

Source: Hematologic Malignancies 15. 12. 2021

News Intestinal Gel LECIG in the Treatment of Advanced Parkinson's Disease in Real Practice

A recently published study presents the first experiences with an intestinal gel containing a triple combination of antiparkinsonian drugs and dosed via an infusion pump through percutaneous endoscopic gastrostomy extended into the jejunum in the treatment of advanced Parkinson's disease.

Source: Parkinson's Disease 10. 3. 2023

News Treatment with Dupilumab in Severe Corticosteroid-Dependent Bronchial Asthma –⁠ A Case Study

We present the case of a 36-year-old woman with severe corticosteroid-dependent asthma with numerous comorbidities and complications due to long-term systemic corticosteroid therapy. Significant improvements in quality of life, asthma control, regression of skin changes in atopic dermatitis, and reduction in methylprednisolone consumption for this patient were only achieved after the initiation of biological treatment. Dupilumab, a monoclonal antibody against the α subunit of the receptor for interleukins IL-4 and IL-13, which is approved for the treatment of severe refractory eosinophilic bronchial asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyposis, was indicated in her treatment.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 4. 4. 2022

News Testing RAS Gene Mutations in Patients with Colorectal Cancer

Correct identification of the RAS oncogene variant is crucial for deciding the treatment of patients with colorectal cancer. Information on the prevalence of individual RAS gene mutations varies significantly in the literature, which may be due to different testing methods. The authors of the presented analysis focused on how the approach to testing RAS variants has evolved over time in Europe.

Source: Colorectal Cancer 17. 5. 2020

News Efficacy and Safety of Soybean and Avocado Unsaponifiables in the Treatment of Knee and Hip Osteoarthritis

Osteoarthritis represents a chronic irreversible degenerative joint disease, the prevalence of which increases with age. Various approaches are applied in therapy, including the administration of preparations aimed at reducing symptoms of the disease and slowing its progression. A recently published study provides current insights into the efficacy and safety of unsaponifiable soybean and avocado oil in the treatment of hip and knee osteoarthritis.

Source: Osteoarthritis Therapy 4. 4. 2020

News ESC 2022: Heart Failure with Preserved Ejection Fraction as an Underdiagnosed Problem: How to Increase Its Detection in Everyday Practice?

During this year's European Society of Cardiology Congress (ESC 2022), alarming information was shared, indicating that heart failure with preserved ejection fraction of the left ventricle (HFpEF) is likely underdiagnosed in clinical practice, necessitating improved identification and detection of patients with this condition. One of the symposiums addressed not only the reasons why many patients with HFpEF are misdiagnosed.

Source: Heart Failure 14. 11. 2022

News Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy that reduces edema may improve overall treatment outcomes concerning visual functions. A recently published multicenter randomized clinical study evaluated the effect of local therapy combining dorzolamide and timolol in patients with this issue.

Source: Glaucoma 3. 7. 2020

News Alarming Data on Prevalence and Insufficient Treatment of Hypertension in Working Age −⁠ Another Underestimated 'Civilization Epidemic'?

The National Cardiology Information System (NKIS), developed by the Czech Society of Cardiology in collaboration with the Institute of Health Information and Statistics (ÚZIS), has provided the first data on the prevalence of hypertension in the Czech population. It revealed that even the treatment of a significant risk factor for cardiovascular diseases –⁠ hypertension –⁠ is not well managed in the Czech Republic. About 40% of patients with hypertension do not have regular preventive check-ups with their general practitioner, while 40% of hypertensive patients are simultaneously of working age.

Source: Risk factors of cardiovascular diseases 10. 6. 2024