Search

News Virtual Echocardiography as a Potential Screening Tool for the Diagnosis of Primary Pulmonary Hypertension

Primary pulmonary hypertension disease is associated with a poor prognosis. Early diagnosis and the implementation of specific therapy are necessary to improve patients' prospects. In the near future, virtual echocardiography, which has shown good results in published studies, may become a valuable screening tool.

Source: Pulmonary hypertension (CTEPH, PAH) 10. 3. 2021

News New ESMO Recommendations for Investigating Circulating Tumor DNA

Liquid biopsy has been discussed in oncology for several decades. As we move from conference abstracts to its real-world application in clinical practice, the new recommendations of the European Society for Medical Oncology (ESMO) describe the examination of circulating tumor DNA from peripheral blood.

Source: Genetic Profile and Treatment of NSCLC 8. 9. 2022

Články časopisu Non-Small Cell Lung Cancer with Estrogen Receptors and ALK Positivity

Author of the article: L. Žarnayová, V. Kolek, J. Bouchal, J. Ehrmann Source: Klinická onkologie | 6/2018 11. 12. 2018

Články časopisu Type 1 and 2 diabetes and pregnancy

Author of the article: L. Féderová, M. Korbeľ, Z. Nižňanská Source: Praktická gynekologie | 2/2010 23. 7. 2010

News The Presence of COPD Worsens the Course of COVID-19 –⁠ Results of Epidemiological Studies

Among the at-risk populations during the current COVID-19 pandemic are older individuals and those suffering from chronic comorbidities. The presence of chronic obstructive pulmonary disease (COPD), according to available data, represents a negative prognostic factor increasing the risk of severe course and mortality.

Source: Treatment of Asthma and COPD 8. 4. 2020

Články časopisu Sever bleeding one year after a cesarean section caused by placenta increta persistens

Author of the article: Š. Urbánek, H. Brádková, P. Beroušková, F. Farajpour Source: Česká gynekologie | 3/2012 1. 6. 2012

News Impact of Comorbidities on the Efficacy of Ceftaroline Fosamil in Complicated Skin and Soft Tissue Infections −⁠ Pooled Analysis of 3 Studies

In 3 randomized Phase III studies, ceftaroline fosamil demonstrated non-inferiority in treating complicated skin and soft tissue infections (cSSTI) compared to vancomycin + aztreonam. A recent pooled analysis of these 3 studies evaluated the impact of age and comorbidities on clinical outcomes.

Source: Anti-Infectives 17. 3. 2023

News Brigatinib in the Therapy of Pretreated Patients with Advanced ALK-Positive NSCLC

A French study analyzed clinical data of pretreated ALK-positive patients with advanced non-small cell lung cancer (NSCLC) and examined the efficacy of next-generation ALK inhibitors –⁠ brigatinib, followed by lorlatinib –⁠ in real-world clinical practice.

Source: Non-Small Cell Lung Cancer 22. 12. 2022

News Water Microjet as a Gentler Method of Debridement

Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic tissue. However, this method can be painful, imperfect, and associated with the risk of damaging healthy tissue. New and gentler methods are emerging, promising improved therapeutic outcomes, such as the use of a water microjet.

Source: Wound Healing 3. 5. 2023

News Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder

Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of action and a rapid onset of therapeutic effect. A newly published analysis evaluated the available clinical data regarding the early effect of once-a-day trazodone in patients with Major Depressive Disorder (MDD).

Source: Depression and Anxiety 24. 11. 2021

News Geriatrics and Nutrition in Old Age -⁠ Invitation

We invite you to watch a webinar dedicated to the topic of nutrition in old age. The impetus for its creation was the fact that from September 1, 2020, physicians specializing in geriatrics are allowed to prescribe outpatient sipping to ensure early nutritional intervention for malnourished patients.

Source: Enteral Nutrition 19. 11. 2020

News Current ASH Guidelines for Management of ITP 2019 −⁠ Recommendations for Newly Diagnosed ITP in Adults

The American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP) at the end of 2019, where a panel of experts attempted to define evidence-based recommendations for the management of these patients.

Source: Immune Thrombocytopenia 20. 2. 2020

News Efficacy and Safety of Enoxaparin in Hospitalized Patients with Severe Renal Insufficiency

A study evaluating the effect of thromboprophylaxis with enoxaparin at a dose of 20 mg/day in adult patients with renal failure compared the incidence of venous thromboembolism (VTE) with published results in patients without renal insufficiency who were prophylactically treated with enoxaparin at a dose of 40 mg/day. The authors also focused on the incidence of bleeding.

Source: Thromboprophylaxis 13. 6. 2022

News Brigatinib in Patients with ALK+ NSCLC –⁠ Final Results of the J-ALTA Clinical Study

At this year's American Society of Clinical Oncology (ASCO) conference held in Chicago in early June 2022, the final results of the J-ALTA clinical study were presented. So how did brigatinib perform in the treatment of patients with ALK-positive NSCLC who were refractory to alectinib?

Source: Non-Small Cell Lung Cancer 12. 9. 2022

News Impact of erdostein on bacterial biofilm −⁠ and what it means for clinical practice?

One of the substances that could potentially influence the success of treatments for infections associated with biofilm formation in the future is erdostein. This medication is used in the treatment of both acute and chronic diseases of the respiratory system (including chronic obstructive pulmonary disease) usually accompanied by increased mucus production. Its effect is mediated by several mechanisms that can also affect bacterial biofilm.

Source: Cough Therapy 28. 11. 2023