Search

Články časopisu Non-Small Cell Lung Cancer with Estrogen Receptors and ALK Positivity

Author of the article: L. Žarnayová, V. Kolek, J. Bouchal, J. Ehrmann Source: Klinická onkologie | 6/2018 11. 12. 2018

News The Presence of COPD Worsens the Course of COVID-19 –⁠ Results of Epidemiological Studies

Among the at-risk populations during the current COVID-19 pandemic are older individuals and those suffering from chronic comorbidities. The presence of chronic obstructive pulmonary disease (COPD), according to available data, represents a negative prognostic factor increasing the risk of severe course and mortality.

Source: Treatment of Asthma and COPD 8. 4. 2020

Články časopisu Sever bleeding one year after a cesarean section caused by placenta increta persistens

Author of the article: Š. Urbánek, H. Brádková, P. Beroušková, F. Farajpour Source: Česká gynekologie | 3/2012 1. 6. 2012

News Impact of Comorbidities on the Efficacy of Ceftaroline Fosamil in Complicated Skin and Soft Tissue Infections −⁠ Pooled Analysis of 3 Studies

In 3 randomized Phase III studies, ceftaroline fosamil demonstrated non-inferiority in treating complicated skin and soft tissue infections (cSSTI) compared to vancomycin + aztreonam. A recent pooled analysis of these 3 studies evaluated the impact of age and comorbidities on clinical outcomes.

Source: Anti-Infectives 17. 3. 2023

News Brigatinib in the Therapy of Pretreated Patients with Advanced ALK-Positive NSCLC

A French study analyzed clinical data of pretreated ALK-positive patients with advanced non-small cell lung cancer (NSCLC) and examined the efficacy of next-generation ALK inhibitors –⁠ brigatinib, followed by lorlatinib –⁠ in real-world clinical practice.

Source: Non-Small Cell Lung Cancer 22. 12. 2022

News Water Microjet as a Gentler Method of Debridement

Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic tissue. However, this method can be painful, imperfect, and associated with the risk of damaging healthy tissue. New and gentler methods are emerging, promising improved therapeutic outcomes, such as the use of a water microjet.

Source: Wound Healing 3. 5. 2023

News Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder

Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of action and a rapid onset of therapeutic effect. A newly published analysis evaluated the available clinical data regarding the early effect of once-a-day trazodone in patients with Major Depressive Disorder (MDD).

Source: Depression and Anxiety 24. 11. 2021

News Geriatrics and Nutrition in Old Age -⁠ Invitation

We invite you to watch a webinar dedicated to the topic of nutrition in old age. The impetus for its creation was the fact that from September 1, 2020, physicians specializing in geriatrics are allowed to prescribe outpatient sipping to ensure early nutritional intervention for malnourished patients.

Source: Enteral Nutrition 19. 11. 2020

News Current ASH Guidelines for Management of ITP 2019 −⁠ Recommendations for Newly Diagnosed ITP in Adults

The American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP) at the end of 2019, where a panel of experts attempted to define evidence-based recommendations for the management of these patients.

Source: Immune Thrombocytopenia 20. 2. 2020

News Efficacy and Safety of Enoxaparin in Hospitalized Patients with Severe Renal Insufficiency

A study evaluating the effect of thromboprophylaxis with enoxaparin at a dose of 20 mg/day in adult patients with renal failure compared the incidence of venous thromboembolism (VTE) with published results in patients without renal insufficiency who were prophylactically treated with enoxaparin at a dose of 40 mg/day. The authors also focused on the incidence of bleeding.

Source: Thromboprophylaxis 13. 6. 2022

News Brigatinib in Patients with ALK+ NSCLC –⁠ Final Results of the J-ALTA Clinical Study

At this year's American Society of Clinical Oncology (ASCO) conference held in Chicago in early June 2022, the final results of the J-ALTA clinical study were presented. So how did brigatinib perform in the treatment of patients with ALK-positive NSCLC who were refractory to alectinib?

Source: Non-Small Cell Lung Cancer 12. 9. 2022

News Impact of erdostein on bacterial biofilm −⁠ and what it means for clinical practice?

One of the substances that could potentially influence the success of treatments for infections associated with biofilm formation in the future is erdostein. This medication is used in the treatment of both acute and chronic diseases of the respiratory system (including chronic obstructive pulmonary disease) usually accompanied by increased mucus production. Its effect is mediated by several mechanisms that can also affect bacterial biofilm.

Source: Cough Therapy 28. 11. 2023

News The Importance of Adequate Protein Intake in Critical Patients –⁠ Analysis of Data from an International Study

Adequate protein intake is a necessary part of care for critically ill patients and mitigates catabolic reactions associated with severe illness or injury. The benefits of proper determination and adherence to protein intake, however, have not been sufficiently assessed in detail. Therefore, this topic was the focus of a work analyzing data from an international observational multicenter study published in the Journal of Parenteral and Enteral Nutrition.

Source: Parenteral Nutrition 16. 9. 2020

News Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene

Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below investigated its intracranial activity.

Source: Lung Cancer 24. 5. 2023

News Cost-Effectiveness of Eletriptan in Acute Migraine Treatment

Even in a market dominated by generics, eletriptan 40 mg is among the most clinically effective and cost-efficient triptans for the acute treatment of migraine attacks. This was demonstrated by a systematic literature review focused on the pharmacoeconomic evaluation of this therapy, published by American authors in 2015. Its high cost-effectiveness may be due to its strong efficacy with a reduced need for additional treatment.

Source: Treatment of Severe Migraine 1. 6. 2022