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News Do Asthma Bronchiale and COPD Represent a Risk Factor for Severe COVID-19 and Death?
It is well known that patients with bronchial asthma and chronic obstructive pulmonary disease (COPD) have a higher risk of severe course of common viral respiratory diseases. A study by Belgian authors involving several hundred individuals evaluated the risk of ICU admission and death due to COVID-19 in patients with asthma and COPD compared to patients without these conditions. The other goal was to determine whether these risks are influenced by inhalation corticosteroid therapy or not.
News “Customized Schizophrenia Treatment”: Benefits of Therapeutic Innovations in Inpatient and Outpatient Care Thanks to Gentler Antipsychotics
In the field of schizophrenia treatment, the possibility of significantly greater individualization, brought about by gentler antipsychotics, is currently a hot topic. A major focus is the differences in schizophrenia therapy during hospitalization and subsequently in outpatient care. These topics were also addressed in a seminar called “Customized Schizophrenia Treatment,” supported by Angelini, which took place in Brno.
News Treatment of Schizophrenia in a Patient at Risk of Developing Metabolic Syndrome – Interactive Case Study
A 34-year-old man has been under psychiatric care for 3 years due to a psychotic disorder. Three years ago, he had his first short hospitalization due to marked paranoid symptoms: feelings of being watched, eavesdropping, auditory hallucinations of an imperative nature...
News Idiopathic Pulmonary Fibrosis: Can This Disease Be Named More Precisely?
Much about idiopathic pulmonary fibrosis (IPF) is still unknown. Some experts would like to reclassify this disease. What classification options are available? What would a focus on the "progressive fibrotic phenotype" in research mean? And what would a change in classification mean for patients?
News Benefit of Oral Semaglutide for Patients with Type 2 Diabetes in the General Practitioner's Office
Oral semaglutide is a modern antidiabetic suitable within primary care for people with type 2 diabetes, primarily due to its comprehensive action that includes not only reducing blood glucose and body weight but also a number of other favorable non-glycemic effects.
News Use of Bilastine in Pediatrics − Pathway to Improving Concentration and Performance of Young Allergy Sufferers
In the treatment of allergic diseases, especially in children, safety, good tolerability, simple dosing regimen, and non-sedative effects are the basic requirements for administered medications. Sedative side effects of treatment have a negative impact on sleep patterns and subsequently on children's performance in school. European professional societies recommend the use of modern second-generation antihistamines in the treatment of children. Studies confirm that bilastine, which meets these requirements, should be among the first-choice drugs.
News Comparison of Enoxaparin and Unfractionated Heparin in Hospitalized Patients in Terms of Clinical and Cost Effectiveness
Thromboembolic disease represents one of the severe complications in hospitalized patients. Low molecular weight and unfractionated heparin are most commonly used during hospitalization as part of pharmacological thromboprophylaxis. An extensive study conducted in the United States evaluated the clinical and cost-effectiveness and safety of both therapy modalities in hospitalized patients at risk of thromboembolic disease.
News Perioperative Management of Bleeding in Patients with von Willebrand Disease Using Coagulation Factors
Von Willebrand disease is one of the most common congenital bleeding disorders. It is a heterogeneous group of diseases with varying severity of clinical manifestations. Some patients require pharmacological prevention or treatment of bleeding as part of perioperative care. The administration of concentrates containing coagulation factors is currently the gold standard for certain types of von Willebrand disease.
News Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer
RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction due to mutation leads to the development and progression of malignant diseases such as colon or lung cancers. At the beginning of 2022, the inhibitor of the mutated KRAS protein, sotorasib, was approved. The following article outlines the effect of this first representative of a new drug group and its potential in the treatment of non-small cell lung cancer (NSCLC).
News Meta-analysis of Incidence of Infusion Reactions to Anti-EGFR Antibodies in Patients with mCRC
The application of antibodies against the epidermal growth factor receptor (EGFR), administered in slow infusions mainly as part of the treatment for metastatic colorectal cancer (mCRC), may be accompanied by infusion reactions or hypersensitivity reactions.
News Results of ATTUNE Total Knee Replacement Implantation – Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man
The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then, tens of thousands of implants have been administered to patients worldwide. The mid-term results are very positive, as evidenced by data from the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man.
News Extract from Aloe barbadensis in the Treatment of Irritable Bowel Syndrome
The authors of a pooled analysis of two randomized controlled trials evaluated whether administration of Aloe barbadensis extract in patients with diarrhea-predominant irritable bowel syndrome (IBS) resulted in a significant reduction in the overall severity of symptoms.
News Composition of the Intestinal Microbiota of Patients with IBS May Predetermine the Success of a Diet with Low Fermentable Carbohydrates
Some patients with irritable bowel syndrome may benefit from a diet low in fermentable carbohydrates, but the mechanism of this intervention is not yet satisfactorily explained. A study published in Gut focused on the relationship between the composition of the intestinal microbiota and clinical response to dietary intervention.
News Subcutaneous Immunoglobulin Substitution in Ig-Naive Patients with PID – Available Efficacy and Safety Data
The prevalence of primary immunodeficiencies (PID) is estimated at 1 : 10,000. Below, we summarize the available findings on the efficacy and safety of subcutaneous immunoglobulin substitution in Ig-naive patients (i.e., without prior immunoglobulin substitution).
News Effectiveness of Tofacitinib in the Treatment of Ulcerative Colitis in Real-World Clinical Practice
One of the new modalities for the treatment of ulcerative colitis (UC) is tofacitinib. Its effectiveness has already been demonstrated in clinical studies and is now being proven in real-world clinical practice, where we can evaluate the results of patients who could not be included in clinical trials or those with refractory disease.
News What impact do the symptoms of primary biliary cholangitis have on the patient and their quality of life
Primary biliary cholangitis (PBC) is a serious chronic cholestatic autoimmune liver disease that predominantly affects middle-aged women and can lead to end-stage liver failure and the need for transplantation. Several studies published this year show a reduction in the quality of life of patients with this disease due to its accompanying symptoms.
News Variability of COPD Symptoms During the Day and Impact on Patients' Morning Routine – Survey Results
Chronic obstructive pulmonary disease (COPD) is viewed, unlike bronchial asthma, as a condition with a more chronic course and less variability of symptoms throughout the day. The study presented below aimed to clarify whether these patients experience deterioration at certain times of the day and how this affects their daily lives.
News Current Insights into the Etiology of Community Pneumonia: Pneumococci Still Leading?
The etiology of community-acquired pneumonias has undergone certain changes since the beginning of the antibiotic era. According to current guidelines, it is still recommended to initiate empirical antibiotic therapy upon diagnosing community-acquired pneumonia. However, there are certain concerns associated with the recommendation of empirical antibiotic therapy, especially regarding the increasing occurrence of bacterial antibiotic resistance. The aim of the study presented below was to specify the most frequently isolated pathogens of community-acquired pneumonia between 1945 and 2020.
News Maintenance Therapy After Oxaliplatin Discontinuation Based on Panitumumab
Panitumumab is an approved therapy for metastatic colorectal cancer without RAS oncogene mutation (wtRAS mCRC) and has been evaluated for 1st-line treatment through randomized phase II (PEAK) and III (PRIME) studies. A retrospective analysis of these studies assessed the efficacy and safety of panitumumab as the basis for therapy in these patients after discontinuation/termination of oxaliplatin.
News Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients with Hypercholesterolemia – Meta-Analysis of 35 Randomized Controlled Trials
The authors from several American institutions examined the efficacy and safety of two proprotein convertase subtilisin/kexin type 9 (PCSK9i) inhibitors, alirocumab and evolocumab, in their work. They conducted a systematic meta-analysis of randomized controlled clinical trials comparing the administration of these two PCSK9i with standard treatment.
News Therapy with Cyclosporine in the Context of the Coronavirus Pandemic
The rapid spread of the SARS-CoV-2 virus and the associated COVID-19 disease pandemic raises concerns about possible risks associated with immunosuppressive treatment of autoimmune diseases. Specifically, does the use of cyclosporine increase the risk of infection, or does it act protectively?