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News Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension
Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of cognitive dysfunction. According to available data, metformin may reduce the risk of developing frailty in postmenopausal women. A recently published Italian study, LEOPARDESS, aimed to evaluate the effect of extended-release metformin on the cognitive functions of this population of women.
News Safe Long-term Treatment of Nasal Symptoms in Patients with Perennial Allergic Rhinitis
In persistent allergic rhinitis, achieving symptom control is often difficult despite pharmacological treatment and minimizing contact with the allergen. Good efficacy in clinical studies has been shown with combined therapy of intranasal antihistamines with locally acting corticosteroids. The presented study evaluated the long-term safety profile and efficacy of a fixed combination of olopatadine with mometasone.
News Effect of Combination Therapy on Symptoms of Allergic Rhinitis
The aim of the study presented below by authors from the USA was to evaluate the efficacy, safety, and tolerability of treatment with the nasal spray GSP301 containing a fixed combination of active ingredients, compared to placebo and monotherapies during a 14-day therapy in adult and adolescent patients with allergic rhinitis.
News Does the choice of therapy for primary hypertension in patients with COVID-19 affect the severity of the disease?
The effect of two commonly used antihypertensives was evaluated in a randomized clinical trial in patients with primary hypertension and COVID-19.
News Prim. Pavel Jindra: Biosimilars are an accessible and effective treatment modality in hematooncology
“Based on our experience so far, biosimilars represent an effective and safe alternative to original molecules. We are not afraid to use them anywhere in approved indications, and we are not afraid of switching either. Biosimilars are a significant step towards greater accessibility of hematooncological treatment for a wide group of patients,” states the head of the Hematology-Oncology Department of FN Plzeň, MUDr. Pavel Jindra, Ph.D., in our current interview.
News Continuation of Treatment with Tofacitinib in Rheumatoid Arthritis – Real-World Clinical Practice Data
The oral Janus kinase inhibitor tofacitinib has been extensively tested in patients with rheumatoid arthritis in numerous international randomized clinical trials. According to a recently published review summarizing retrospective, prospective, and observational studies from real-world clinical practice published in 2018–2020, the treatment duration with tofacitinib is comparable to that with biological disease-modifying drugs.
News Is it beneficial to combine etanercept and methotrexate in the treatment of psoriatic arthritis?
The study presented below by Canadian, American, and British authors focused on comparing the efficacy of monotherapy with methotrexate, etanercept, and their combination in patients with psoriatic arthritis.
News Participation in sports activities, frequency and severity of sports injuries in children with hemophilia
Children with hemophilia used to be discouraged from engaging in sports activities due to the potential increased risk of bleeding. The introduction of prophylaxis into routine practice has improved the possibility for children to participate in various sports activities. A study conducted by Dutch authors evaluated the involvement of boys with hemophilia in sports activities and their potential link with sports injuries and bleeding.
News Results of Knee and Hip Joint Arthroplasty in Hemophiliacs
Total endoprosthesis implantation represents an effective solution for the terminal stages of joint degeneration in hemophiliacs. However, compared to the general population, this group of patients exhibits certain specificities, a higher rate of complications, and historically worse surgical outcomes. Recent studies show that with advancements in surgical techniques, implants, and perioperative care, the results are approaching those of the population without a history of bleeding disorders.
News Acquired Hemophilia A Newly Diagnosed in an Elderly Patient − A Case Report
At the XXVIIIth Pařízek Days held in Ostrava, a case of acquired hemophilia A, recently addressed at this institution, was presented in the afternoon session on March 17, 2022, by Assoc. Prof. Petr Dulíček, MD, PhD., from the 4th Department of Internal Medicine, Charles University Faculty of Medicine and University Hospital in Hradec Králové.
News PHD 2022: In the treatment of multiple myeloma we have achieved significant progress, confirm real-world data
The treatment options for multiple myeloma (MM) have significantly advanced over the past 10 years, and patient outcomes have improved. However, the most accurate guide is needed to select the right treatment modality for each particular patient among the many available options. During the Prague Hematology Days (PHD) 2022, this topic was addressed by Prof. MUDr. Roman Hájek, CSc., from the Hemato-Oncology Clinic of the Faculty of Medicine at the University of Ostrava and FN Ostrava.
News Hodgkin Lymphoma in a Summary of News from Post-ASH 2021
Dr. Anna Suredová from the Clinical Hematology Department of the Catalonian Oncology Institute in Barcelona, newly elected president of the European Society for Bone Marrow Transplantation (EBMT), also remotely participated in this year's Prague Hematology Days (PHD 2022). In her lecture, she presented an overview of highlights from 4 clinical studies regarding Hodgkin lymphoma (HL) presented during the Post-ASH 2021 meeting.
News COVID-19 in Patients with Acquired Hemophilia A − Case Reports
At the XXVIII. Pařízek Days held in Ostrava, on the afternoon of March 17, 2022, Dr. Anna Maria Pejková from the 4th Internal Clinic of the University Hospital Hradec Králové presented 3 case reports of acquired hemophilia A.
News Efficacy of L. reuteri DSM 17938 in the Treatment of Infantile Colic
Infantile colic represents a syndrome of behavioral disorders in infants characterized by episodes of uncontrollable crying, wailing, and restlessness without an identifiable cause. This is a common health issue affecting an estimated 5–40% of infants. There are no uniform criteria for the treatment of this benign condition yet, but available studies show a beneficial effect from administering probiotics containing Limosilactobacillus reuteri (previously known as Lactobacillus reuteri) compared with placebo and other treatment methods.
News Clinical and Microbiological Effect of L. reuteri in the Treatment of Chronic Periodontitis
The Journal of Clinical Periodontology published the results of a study evaluating the effect of the probiotic bacterial strain Lactobacillus reuteri as an adjunctive treatment for chronic periodontitis.