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News Experience from Clinical Practice with Intestinal Gel LECIG in Treating Parkinson's Disease
A Swedish observational study evaluated the applicability of the LECIG intestinal gel, which contains levodopa (20 mg/ml), carbidopa (5 mg/ml), and entacapone (20 mg/ml), in clinical practice for patients with Parkinson's disease.
News Development and Benefits of Intestinal Gel LECIG for Patients with Parkinson's Disease
Patients with advanced Parkinson's disease, for whom the current regimen of orally and transdermally administered medications is insufficient for symptom relief, now have a new treatment option. It involves the continuous administration of an intestinal gel that combines three effective antiparkinsonian drugs.
News Untreated Bleeding in Hemophilia A – An Underestimated Problem? To What Extent?
How common is bleeding in hemophilia A that ultimately goes untreated? This was the focus of a recent study, the results of which were published in the journal Research and Practice in Thrombosis and Hemostasis.
News Substitution Treatment of von Willebrand Disease with vWF and FVIII Concentrates
Recently published recommendations from Poland regarding the diagnosis and treatment of von Willebrand disease (vWD) provide a comprehensive summary of the current approach to substitution therapy using concentrates containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII), administered primarily during bleeding or surgical procedures.
News Can the Treatment of Hypertension Prevent Recurrence of Atrial Fibrillation?
Atrial fibrillation (Afib) is the most common serious heart rhythm disorder and is responsible for a significant portion of deaths in the population. Hypertension is the most common and potentially modifiable risk factor for Afib. A newly published meta-analysis compares the effect of angiotensin receptor antagonism and calcium channel blockade on Afib recurrence in patients with hypertension and Afib.
News How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?
The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs), approximately 40% of patients suffer from drug-resistant epilepsy. The recently approved cenobamate brings new hope to patients. A Spanish pharmacoeconomic study aimed to compare the cost-effectiveness of cenobamate with selected third-generation ASMs as adjunctive therapy in patients with drug-resistant focal epilepsy.
News Chronic Thromboembolic Pulmonary Hypertension – Overview of Pathophysiology, Diagnosis, and Treatment
Chronic thromboembolic pulmonary hypertension (CTEPH) is defined by the 2015 ESC/ERS guidelines as symptomatic pulmonary hypertension with persistent defects in lung perfusion despite adequate anticoagulation therapy. Significant values for determining a diagnosis of pulmonary hypertension are a mean pulmonary artery pressure > 25 mmHg. However, this condition remains significantly underdiagnosed, mainly due to its nonspecific symptoms.
News Efficacy of Dabigatran on Left Atrial Appendage Thrombus in Patients with Atrial Fibrillation
The direct thrombin inhibitor dabigatran has shown interesting efficacy in a smaller clinical study in patients with atrial fibrillation and a thrombus in the left atrial appendage. Chinese authors evaluated the results of anticoagulant therapy using transthoracic and transesophageal echocardiography.
News Metamizole, even after 100 years on the market, remains an important component of postoperative pain therapy
Metamizole has been used in the therapy of a wide range of acute and chronic pains for 100 years. Thanks to a number of advantages, it still represents one of the most frequently used analgesics in daily clinical practice.
News Pegylated Liposomal Irinotecan + 5-FU/LV in the Treatment of mPDAC in Czech Clinical Practice – Results from the VILP Registry
At last year's annual congress of the European Society for Medical Oncology (ESMO) and this year's 15th PragueONCO, results from the Czech VILP registry were presented. This registry collected data on patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with pegylated liposomal irinotecan (nal-IRI) in combination with 5-fluorouracil (5-FU) and leucovorin (LV). The efficacy and safety of nal-IRI + 5-FU/LV in patients with mPDAC after failure or intolerance to gemcitabine-based chemotherapy, as found in the randomized controlled study NAPOLI-1, are thus confirmed in real clinical practice in the Czech Republic.
News Etiology of Recurrent Reproductive Losses – Focus on Genetics
Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are considered a complex disease. We provide a brief overview of the current knowledge on their possible etiology and genetic correlations, both on the part of the mother and father.
News Meta-analysis of Efficacy and Safety of Antidiabetics in Treating Gestational DM
What efficacy and safety do insulin, metformin, or the sulfonylurea derivative glibenclamide (glyburide) offer in lowering glucose levels in women with gestational diabetes? The authors of a meta-analysis of randomized controlled trials used a probabilistic model – a Bayesian network – to answer this question.
News Meta-analysis of the efficacy and safety of dupilumab in the treatment of atopic dermatitis in children and adults
Moderate to severe atopic dermatitis (AD) is accompanied by strong inflammatory processes that can occur anywhere on the skin, intense itching, and pain. The biologic dupilumab is a promising molecule for the treatment of severe forms of this condition – results from a recently published meta-analysis indicate that this therapy is not only effective but also well-tolerated by patients.
News Dupilumab in the Treatment of Adolescent Patients with Severe and Refractory Atopic Dermatitis
An open multicenter study evaluating dupilumab in the treatment of moderate to severe atopic dermatitis in adolescents confirmed its long-term efficacy and safety in this age group. In addition to its results, we also summarize information on dosing and reimbursement conditions in the Czech Republic for the age group 12-18 years.
News Current Trends in Proton RT of Head and Neck Tumors: Aiming to Preserve T Lymphocytes, Without Them, Treatment is Ineffective
Tumors of the head and neck are often diagnosed at an advanced stage. With the availability of modern treatments, such as immunotherapy or radiotherapy modalities, prognosis and chances for long-term survival are improving. We discuss trends not only in proton therapy for oropharyngeal tumors and the prospects of combining treatment methods for these diagnoses with the head doctor of the Proton Center Prague Associate Professor MUDr. Jiří Kubeš, Ph.D.
News Echocardiography in the Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?
News Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome – A Case Study
Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for hyperprolactinemia induced by risperidone. A significant benefit of lurasidone is its favorable cardiometabolic profile. Switching from another antipsychotic to lurasidone can be performed on an outpatient basis. Most importantly, it is essential to highlight its effect on both positive and negative symptoms of schizophrenia, as demonstrated by the presented case study.
News Critical Conditions in Obstetrics 2022: What is Available in the Czech Republic for Managing Peripartum Life-Threatening Bleeding?
On December 10, 2022, a professional meeting entitled Critical Conditions in Obstetrics 2022 was held in the lecture hall of the new building of the National Museum in Prague. Prof. MUDr. Antonín Pařízek, CSc., from the Department of Gynecology and Obstetrics of the 1st Faculty of Medicine, Charles University, and General University Hospital in Prague, gave a presentation addressing the issue of peripartum life-threatening bleeding (PLTB), the necessities for its management, and provided an overall perspective on the current situation in obstetrics in our country.
News The safety of dupilumab allows treatment of atopic dermatitis without routine laboratory monitoring
The first comprehensive analysis of laboratory data from 3 clinical trials with dupilumab assessed the incidence of clinically significant changes in hematological or biochemical parameters in patients with moderate to severe atopic dermatitis.
News Risk of Subsequent Fractures in Postmenopausal Women After Initial Fracture
Osteoporosis is associated with an increased risk of fractures. The prospective analysis presented below examined the risk of subsequent fractures in postmenopausal women after an initial fracture depending on its location.
News Current findings on the treatment of gestational diabetes and DM2 in pregnancy with metformin
Recent reviews have shown that metformin is a safe alternative to insulin in the treatment of diabetes during pregnancy. For gestational diabetes (GDM) and type 2 diabetes mellitus (DM2), metformin administered to pregnant women has its benefits, but also certain risks.
News Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and reduced gastrointestinal (GI) motility, but also to an improvement in glycemic parameters.