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News Administration of Low-Molecular-Weight Heparin After Hemorrhagic Stroke: What Is the Appropriate Timing?

Hemorrhagic stroke (HS) is a condition that raises doubts and concerns about anticoagulation. Is early prevention of thromboembolic complications appropriate?

Source: Thromboprophylaxis 30. 9. 2021

News Romiplostim brings benefit also to patients with ITP lasting less than 1 year

What is the role of second-line therapy, in this case romiplostim, in the management of adult ITP patients who have not yet reached the chronic phase of the disease?

Source: Immune Thrombocytopenia 21. 11. 2023

News Meta-Analysis of the Results of Studies Comparing the Effectiveness of Manual and Sonic Toothbrushes

Brushing teeth is a fundamental means of maintaining good oral hygiene. While many people still rely on using manual toothbrushes, brushing with electric toothbrushes has also gradually gained significant popularity. Several studies comparing the effectiveness and gentleness of these two approaches have been conducted in the past, followed by a meta-analysis of their results.

Source: Dental Care 21. 4. 2023

News Hybrid Cooperative Complexes in the Treatment of Osteoarthritis

Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the related choice of appropriate intra-articular viscosupplementation, with emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.

Source: Pain Management 18. 6. 2024

Články časopisu Current results of colorectal cancer screening and potential value of colon capsule endoscopy in the Czech Republic

Author of the article: O. Ngo, R. Chloupková, Suchánek Š., Zavoral M., Dušek L., O. Májek Source: Gastroenterologie a hepatologie | 5/2019 31. 10. 2019

News Study COPDGene Redefines Diagnostic Criteria of Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease ranks among the top causes of morbidity and mortality worldwide. Current diagnostic criteria for the disease are based exclusively on spirometric examination. Increasing evidence, however, suggests that a significant number of patients show signs of chronic obstructive pulmonary disease without pathological findings on spirometry. The analysis of the COPDGene study thus proposes expanding the diagnostic criteria to include additional parameters.

Source: COPD 28. 5. 2020

News Thyroid Disorder Screening in Pregnancy to Be Tested by Pilot Program Starting September

The expectations surrounding the trial launch of the screening program were discussed by Professor Michal Kršek, Chairman of the Czech Endocrinological Society ČLS JEP, on the occasion of the 12th annual “Thyroid Week”.

Source: Thyroid Disorders 8. 6. 2020

News Forgotten Pulmonologists: COVID-19 Detection in Patients with Lung Disease

The Czech Pneumological and Phthisiological Society of ČLS JEP (ČPFS) submitted a request to the Ministry of Health of the Czech Republic on March 25, 2020, to allow pulmonologists to send patients with suspected COVID-19 directly for infection testing. In their statement, they also provide recommendations on how to manage care for patients with chronic lung diseases during the outbreak of the SARS-CoV-2 virus and how these patients should behave.

Source: Asthma under control 7. 4. 2020

News Less Ventricular Arrhythmias and ICD Shocks After Introduction of Sacubitril/Valsartan

Is the decrease in the incidence of sudden cardiac death among patients using sacubitril/valsartan due to a lower risk of ventricular arrhythmias? And does it have anything to do with reverse left ventricular remodeling? A newly published study utilizing data from telemonitoring of patients with implanted devices focused on this.

Source: Chronic Heart Failure and Lipidology 8. 1. 2020

News Relationship Between Mortality and Use of Statins or RAAS Inhibitors After Aortic Valve Replacement

The impact of prescribed medication after transcatheter aortic valve replacement (TAVR) has not been precisely assessed to date. A recently published retrospective analysis of clinical practice data from patients who underwent TAVR aimed to assess the potential benefit of using statins and renin-angiotensin-aldosterone system (RAAS) inhibitors.

Source: Sartans in the Treatment of Hypertension 16. 3. 2023

News Osimertinib in the Treatment of Patients with NSCLC with Secondary EGFR T790M Mutation –⁠ Case Study

Non-small cell lung cancer (NSCLC) is a genetically heterogeneous disease. Individualization of therapy based on the presence of specific tumor cell mutations is therefore crucial for choosing the optimal therapy for these patients. One of the targeted treatment options for patients with NSCLC with an activating mutation in the epidermal growth factor receptor (EGFR) gene is osimertinib, a third-generation EGFR tyrosine kinase inhibitor (EGFR TKI). We present a case study of a patient with NSCLC treated with osimertinib after disease progression due to a secondary EGFR T790M mutation resulting from afatinib therapy. The described case well illustrates the role of osimertinib in the treatment of NSCLC with secondary EGFR T790M mutation.

Source: Lung Cancer 10. 6. 2020

News Good Efficacy of Brigatinib After Failure of 2nd Generation ALK Inhibitors

Brigatinib is commonly used in the treatment of ALK-positive non-small cell lung cancer (NSCLC) in the 2nd line after progression on a 1st-generation ALK inhibitor, crizotinib. American scientists in a phase II study focused on the efficacy of brigatinib in the treatment of patients with advanced NSCLC who had progressed on 2nd-generation ALK inhibitors.

Source: Non-Small Cell Lung Cancer 15. 2. 2021

News Combination of Candesartan with ACE Inhibitors in the Treatment of Hypertension and Heart Failure

Although the combination of ACE inhibitors and sartans is not recommended due to the higher incidence of complications, studies also indicate a positive effect of their concurrent administration. The potential use of dual blockade of the renin-angiotensin-aldosterone system (RAAS) is suggested in resistant hypertension, and results have also been described in the treatment of congestive heart failure. What do the recommendations say?

Source: Sartans in the Treatment of Hypertension 25. 5. 2020

News Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer

The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance treatment of patients with newly diagnosed advanced ovarian, fallopian tube, or peritoneal cancer with BRCA 1/2 mutation leads to an improved prognosis for these patients.

Source: Ovarian and Breast Cancer 17. 3. 2020

News Obinutuzumab and Early Progression of Patients with Previously Untreated Follicular Lymphoma −⁠ Analysis of Data from the GALLIUM Study

The GALLIUM study demonstrated longer progression-free survival (PFS) in patients with previously untreated follicular lymphoma (FL) treated with obinutuzumab compared to rituximab. The aim of the exploratory data analysis was to evaluate the impact of obinutuzumab on the incidence of early disease progression and the relationship between early progression and overall survival (OS) of the patients.

Source: Non-Hodgkin Lymphomas and CLL 23. 4. 2020