EAU – LUTS treatment should be predominantly based on combination therapy


Authors: D. Pacík;  G. Varga
Authors‘ workplace: Urologická klinika LF MU a FN Brno
Published in: Urol List 2014; 12(3): 6-8

Overview

At recent EAU meeting in Stockholm (Sweden) new data were presented, clearly demonstrating that urologists treating symptoms associated with lower urinary tract syndrome focus too much on voiding (obstructive) symptoms while neglecting filling (irritating) symptoms, which might have substantially larger negative impact on patient quality of life. Results of NEPTUNE II Study show, that combination therapy of this condition is effective and well tolerated when used both short- and long-term.

Key words:
lower urinary tract syndrome, filling symptoms, voiding symptoms, hyperactive bladder


Sources

1. Gravas S, Bachmann A, Descazeaud A et al. Guidelines on the management of non‑neurogenic male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO). European Association of Urology 2014. [online]. Available from: http:/ / www.uroweb.org/ gls/ pdf/ 13%20Non‑Neurogenic%20Male%20LUTS_LR%20(2).pdf.

2. Irwin DE, Milsom I, Hunskaar S et al. Popula­tion‑based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol 2006; 50(6): 1306– 1314.

3. Hanuš T, Zámečník L, Doležal T et al. Occurrence of overactive bladder in patients with benign prostatic hyperplasia in the Czech Republic. Urol Int 2011; 86(4): 407– 413. doi: 10.1159/ 000320996.

4. Jumadilova Z, Harris H, del Aguila M et al. Agent selection for overactive bladder patients with and without documented comorbid benign prostatic hyperplasia. Neurourology and Urodynamics 2005; 24(5– 6): A486.

5. MacMillan L, Jackson J, Anderson P et al. Underdia­gnosis and sub‑optimal treatment of LUTS/ BPH: results of a real world survey of patients in Europe. 29th Annual EAU Congress. Stockholm, Sweden: EAU 2014. Available from: http:/ / www.uroweb.org/ events/ abstracts‑online.

6. Drake MJ, Chapple C, Sokol R et al. Long‑term safety and efficacy of single‑tablet combinations of solifenacin and tamsulosin oral controlled absorption system in men with storage and voiding lower urinary tract symptoms: results from the NEPTUNE study and NEPTUNE II open‑label extension. Eur Urol 2014. doi: 10.1016/ j.eururo.2014.07.013.

7. Drake MJ, Chapple C, Oelke M et al. Patient satisfaction with the safety and efficacy of fixed‑dose combinations of solifenacin and tamsulosin OCASTM: results from the Neptune II study. Eur Urol 2014; 13 (Suppl 1): e772.

Labels
Paediatric urologist Urology
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