Analysis of pharmacotherapy for female stress urinary incontinence


Authors: J. Švihra;  J. Ľupták;  J. Kliment
Published in: Urol List 2008; 6(1): 29-34

Overview

The International Continence Society defined urinary incontinence as the complaint of involuntary leakage of urine. Stress urinary incontinence (SUI) is the most common type of urinary incontinence in women. Approximately 300 thousands Slovak women over the age of 18 years have the symptoms of stress urinary incontinence. Pharmacotherapy often use duloxetine (an inhibitor of serotonin and norepinephrine reuptake) for the treatment of female stress urinary incontinence. According to the Cochrane analysis of ten randomized placebo-controlled trials 3 944 women received placebo or duloxetine 80 mg per day from 3 to 36 weeks. Despite the variation in the placebo response, duloxetine 80 mg per day was superior to placebo in all trials. The median percentage reduction in weekly IEF was 50–54% and was not influenced by previous treatment experience or baseline incontinence severity. Slovak clinical trial confirmed good clinical practice of duloxetine because total continence was reached of 3.2 % and incontinence improvement of 61.3 % cases.

Key words:
stress urinary incontinence, meta-analysis, duloxetine


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