Outcomes of first-line treatment of non-Hodgkin and Hodgkin lymphomas in real-world practice – an analysis of patients treated at the Department of Haematooncology, University Hospital Ostrava, from 2013 to 2022
Authors:
B. Šušolová 1; J. Ďuraš 1,2; I. Kováčová 1; K. Hradská 1,2; M. Kaščák 1; M. Navrátil 1,2; M. Lachnit 1; R. Hájek 1,2
Published in:
Transfuze Hematol. dnes,31, 2025, No. 2, p. 81-96.
Category:
Original Papers
doi:
https://doi.org/10.48095/cctahd2025prolekare.cz8
Overview
Lymphomas are a heterogeneous group of lymphoid tissue tumours that differ in histopathological and immunohistochemical features, clinical presentations, prognosis, and treatment strategies. While a large body of data from clinical trials in specific populations is available, few studies have been published regarding outcomes in unselected patient groups from everyday clinical practice. This retrospective analysis presents the results of first-line treatment in 668 patients with non-Hodgkin lymphoma (NHL) and 142 patients with Hodgkin lymphoma (HL) treated between 2013 and 2022 at the Department of Haematooncology, University Hospital Ostrava. The study primarily focuses on key clinical evaluation parameters, including treatment response (TR), progression-free survival (PFS), and overall survival (OS) in patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and HL. In a subanalysis, we further evaluated the impact of previously published known risk factors on treatment outcomes. In the DLBCL group, 82% (221/274) of patients were treated with the R-CHOP/“R-CHOP-like” regimen, with 80% (177/221) achieving complete remission (CR). The median PFS and OS were 122 months, with 5-year PFS and OS rates of 61% and 66%, respectively. Low IPI risk and, to some extent, the GCB (germinal centre B-cell-like) immunophenotype were associated with favourable PFS and OS. Of the 134 patients with FL, 60% (80/134) received first-line chemotherapy in combination with anti-CD20 monoclonal antibody, achieving an overall response rate (ORR) of 95% (76/80) and CR in 76% (62/80). No median PFS or OS was reached for this group, but the 5-year PFS and OS rates were 63% and 86%, respectively. Localised disease at diagnosis and low FLIPI risk were associated with a trend towards better survival. Of the 142 HL patients, 96% (136/142) had classical HL (cHL). In the cHL group, the median PFS and OS were not reached, but the 5-year PFS and OS were 75% and 86%, respectively. In the GHSG subgroups, the 5-year PFS and OS were 94% and 100% in early-stage disease, 84% and 90% in intermediate-stage disease, and 68% and 81% in advanced-stage disease. The observed treatment outcomes for lymphoma patients between 2013 and 2022, using standard treatment protocols, are generally comparable to the results of clinical trials and analyses by other authors from routine clinical practice.
Keywords:
Hodgkin lymphoma – Prognosis – overall survival – Diffuse large B-cell lymphoma – progression-free survival – follicular lymphoma
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JĎ – organizace sběru dat, připomínkování rukopisu, konečná kontrola rukopisu
IK – statistické zpracování dat
KH, MN, MK, ML – organizace sběru dat, připomínkování rukopisu
RH – konečná kontrola rukopisu
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MUDr. Barbora Šušolová
Klinika hematoonkologie
FN Ostrava
17. listopadu 1790/5
708 00 Ostrava
e-mail: barbora.susolova@fno.cz
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