Automated digital cytomorphology increases the reliability of bone marrow diagnostics
Authors:
D. Starostka 1; R. Doležílek 2; P. Miczková 1; J. Juráňová 3; K. Chasáková 1; D. Koláček 4
Published in:
Transfuze Hematol. dnes,31, 2025, No. 2, p. 66-80.
Category:
Review/Educational Papers
doi:
https://doi.org/10.48095/cctahd2025prolekare.cz12
Overview
Expert cytomorphological analysis with natural intra- and inter-expert variability remains one of the cornerstones of multidisciplinary diagnostics in haematology. Automated digital morphology using artificial intelligence represents a major transformational paradigm shift in bone marrow cytomorphology as it minimises subjectivity and variability in assessments. There are several analytical platforms for this method. In addition to speed and objectification of analysis, software advantages include instructive display of cellular context, offering alternative cell classification and cell size measurement and the ability to evaluate high cell counts and detailed assessment of megakaryopoiesis. Major limitations of this method include the quality of imaging and misclassification of cells, which can have critical diagnostic and clinical implications. Extensive validation of analytical equipment for digital bone marrow cytomorphology is necessary, particularly for the Caucasian population. Even in an era of disruptive technological developments, expertise consistently remains the cornerstone of morphologic diagnosis in haemato-oncology.
Keywords:
artificial intelligence – bone marrow – automated digital cytomorphology – cell classification – diagnostic haemato-oncology
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PODÍL AUTORŮ NA PŘÍPRAVĚ RUKOPISU
DS, RD, PM – příprava rukopisu
JJ, KCH, DK – revize rukopisu
ČESTNÉ PROHLÁŠENÍ
Autoři práce prohlašují, že v souvislosti s tématem, vznikem a publikací tohoto článku nejsou ve střetu zájmů a vznik ani publikace článku nebyly podpořeny žádnou farmaceutickou ani biomedicínskou firmou.
PODĚKOVÁNÍ
Publikace vznikla s podporou institucionálního grantu IGS 2023 Nemocnice Havířov, p. o.
Do redakce doručeno dne: 20. 10. 2024.
Přijato po recenzi dne: 23. 4. 2025.
MUDr. David Starostka, Ph.D.
Laboratoř hematoonkologie
a klinické biochemie
Nemocnice Havířov, p. o.
Dělnická 1132/24
73601 Havířov
e-mail: david.starostka@nemhav.cz
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
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