Diagnosis and prognostic factors in mantle cell lymphoma


Authors: A. Obr 1;  M. Mikešová 1;  M. Jarošová 1;  V. Procházka 1;  B. Tessoulin 2;  T. Papajík 1
Authors‘ workplace: Université de Nantes et INSERM Centre Régional de Recherche en Cancérologie Nantes/Angers Unite Mixte de Recherche 892, Nantes, France ;  Hemato-onkologická klinika LF UP a Fakultní nemocnice Olomouc 1;  CHU de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie, Nantes, France 2
Published in: Transfuze Hematol. dnes,22, 2016, No. 3, p. 190-200.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Mantle cell lymphoma (MCL) was first described as a diagnostic entity in the R.E.A.L. (Revised European-American Classification of Lymphoid Neoplasms) classification in 1994. MCL is a malignant disease arising from B-lymphocytes. It is characterised by overexpression of cyclin D1 and by chromosomal translocation t(11;14)(q13;q32). The origin of tumour cells is inner mantle zone of lymphatic follicles. MCL is substantially heterogeneous disease by its morphologic and biologic characteristics. Clinical course can be really slow in indolent form of the disease or conversely very quick in aggressive form of MCL. Strict diagnostics and careful evaluation of prognostic markers are important in patients with this kind of lymphoma because of its biologic and clinical heterogeneity

KEY WORDS:
mantle cell lymphoma – immunophenotype – cytogenetic changes – positron emission tomography – prognosis


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Haematology Internal medicine Clinical oncology

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