Immunogenetic factors influencing red blood cell alloimmunization
Authors:
A. Malušková 1; P. Kovářová 1; M. Kořístka 1; F. Mrázek 2; Z. Čermáková 1,3
Authors‘ workplace:
Krevní centrum, Fakultní nemocnice Ostrava
1; Ústav imunologie, Fakultní nemocnice Olomouc, Lékařská fakulta UP v Olomouci
2; Lékařská fakulta OU v Ostravě
3
Published in:
Transfuze Hematol. dnes,22, 2016, No. 3, p. 157-167.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
The development of red blood cell alloantibodies is induced by the transfusion of antigen incompatible blood products. Similarly, incompatibility between maternal and foetal erythrocyte antigens may be the cause of alloantibody occurrence in pregnant women. The presence of antibodies may have clinical consequences such as haemolytic transfusion reactions or haemolytic disease of the foetus and new-born. In transfusion medicine, antibodies present certain complications in the selection of suitable blood products, especially in patients who require long-term RBC transfusion therapy. Individuals exposed to RBC alloantigens can be divided into responders (producing alloantibodies) and non-responders (without alloantibody production). The aim of this work was to summarize current knowledge concerning alloimmunization based on immunogenetic predisposing risk factors, focusing on the occurrence of specific alloantibodies in association with particular MHC HLA Class II molecules.
KEY WORDS:
transfusion – alloimmunization – RBC antibodies – HLA system
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