Venous thromboembolism in females in association with oral contraceptive use

Authors: P. Ďulíček 1;  P. Sadílek 1;  M. Beránek 2;  M. Pecka 1
Authors‘ workplace: IV. interní hematologická klinika, 2Oddělení klinické biochemie Fakultní nemocnice a Lékařská fakulta Univerzity Karlovy v Hradci Králové 1
Published in: Transfuze Hematol. dnes,19, 2013, No. 1, p. 33-38.
Category: Comprehensive Reports, Original Papers, Case Reports


Venous thromboembolism (VTE) is a multifactorial disease and a major cause of morbidity and mortality. Pulmonary embolism in not only one risk factor, but also postrombotic syndrome can result in decrease quality of life. The incidence of VTE in the population is approximately 1 per 1 000 per year. Absolute risk of VTE is less than 1 per 10 000 per year in women of reproductive age. Pregnancy and oral contraceptive use are common risks of venous thromboembolism in this population (the absolute risk is 3 to 6 VTE/ 10 000 women on contraceptives per year). 33% of Czech women of reproductive age are on oral contraceptives. Risk of the onset of venous thrombosis depends on: duration of use, age of female, type use of contraceptive pill, obesity and is also increased in the case of inherited thrombophilia. We analysed a cohort of 400 Czech females with thrombosis in association with oral contraceptive use with the regard to mean age at the time of thrombosis, frequency of inherited and acquired thrombophilia, frequency of additional risk factors for VTE and duration of oral contraceptive use until the onset of thrombosis.

Key words:
venous thromboembolismus, hormonal contraceptive pill, thrombophilia


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Haematology Internal medicine Clinical oncology
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