Inherited prothrombotic risk factors in children – when to investigate?

Authors: J. Blatný
Authors‘ workplace: Oddělení dětské hematologie Fakultní nemocnice Brno
Published in: Transfuze Hematol. dnes,17, 2011, No. 2, p. 69-71.
Category: Comprehensive Reports, Original Papers, Case Reports


Incidence of VTE in children has increased significantly over the past twenty years. Published data however suggest that inhereted prothrombotic risk factors play a less significant role in paediatric venous thromboembolism than originally presumed. Inherited risk factors alone are deemed to be responsible for less than 15 % of VTE in children. Author critically reviews international as well as Czech national recommendations on the indication of inherited prothrombotic risk factors assesment in children.

Key words:
children, thrombosis, prothrombotic risk factors, hormonal contraceptives


1. Andrew M, David M, Adams M, et al. Venous thromboembolic (VTE) complications in children: first analyses of the Canadian registry of VTE. Blood 1994; 83: 1251-1257.

2. Yang J, Paredes N, Chan AK. Antithrombotic therapy in children with venous thromboembolism. Hamostaseologie 2009; 29: 80-87

3. Vu LT, Nobuhara KK, Lee H, et al. Determination of risk factors for deep venous thrombosis in hospitalized children. J Pediatr Surg 2008; 43: 1095-1099.

4. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia registry. Pediatr Res 2000; 47:763-766.

5. Antithrombotic and thrombolytic therapy, 8th Ed: ACCP Guidelines. Chest 2008; 133: Suppl. 67S- 968 S.

Haematology Internal medicine Clinical oncology
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