Chronobiological aspects in haematology


Authors: P. Švorc;  E. Švorcová 1
Authors‘ workplace: Ústav fyziológie, Lekárska fakulta UPJŠ, 1Klinika hematológie a onkohematológie, Univerzitná nemocnica L. Pasteura, tr. SNP 1, Košice
Published in: Transfuze Hematol. dnes,17, 2011, No. 2, p. 98-104.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Man is exposed to the periodical processes of external environment practically with the synchronization of all his functions during the entire lifespan. The circadian rhythms (24 hour rhythms) are studied most frequently and they are demonstrated also in haematology. Detailed understanding of the circadian timing in fluctuation of some haematological functions in healthy man can have a clinical impact. In the present time, more and more information pass into foreground that changes, for example, in circadian oscillations of haemostatic system may lead to disturbance, resulting in either hypercoagulability and thrombosis or alternatively hypocoagulability and hemorrhage. Variables participating in haemostasis and thrombosis interact and their timing and phase relations may either contribute to maintaining the balance between procoagulant and anticoagulant factors or they may shift the balance in the direction of increased or decreased blood coagulation or thrombolysis. Therefore knowledge about circadian oscillations of haematological functions can serve for timing the more effective treatment of various blood diseases or can indicate that changes in timing of these functions can help to predict certain haematological disease. In the first part of the article we concentrated on elucidation of the basic terms, which are most frequently used in the chronobiological literature. The main objective of the article is to establish the existence of circadian variation in fundamental haematological processes, like haemopoesis, haemostasis and fibrinolysis in healthy persons.

Key words:
chronobiology, haematology


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Labels
Haematology Internal medicine Clinical oncology
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