Fertility-preserving treatment in women with endometrial cancer

Authors: Pavla Svobodová
Authors‘ workplace: Gynekologicko-porodnická klinika 3. LF UK a FN KV, Praha
Published in: Prakt Gyn 2016; 20(1): 19-22
Category: Oncogynecology: Review Article


The diagnosis of endometrial carcinoma in young women of childbearing age is rare, but the incidence in growing. Fertility-preserving therapy of endometrial carcinoma could be considered in patients with a histological diagnosis of grade 1 stage IA endometrial carcinoma without myometrial invasion who wish to preserve their fertility, are willing to accept intensive treatment, close follow-up and risk of unstaged disease. Conservative treatment is based on 6 months medical treatment with high-dose oral progestins. Response rate is referred between 60 and 80 %, recurrence rate 25–40 %; live birth rate around 30 %. Patients should be informed about real risk of recurrence and the need of future hysterectomy.

Key words:
endometrial carcinoma – fertility-saving treatment


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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