Malignant ovarian neoplasms in infertile females in Czech Republic: part II


Authors: as. MUDr. Robert Hudeček 1;  prof. MUDr. Pavel Ventruba;  DrSc. 1;  MUDr. Martin Huser 1;  MUDr. Eva Račanská 1;  MUDr. Radka Vavrušová 1;  doc. RNDr. Jana Šarmanová;  CSc. 2;  MUDr. Jiří Novák 3;  MUDr. Hana Koukalová 3
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno 1;  Fakulta elektrotechniky a informatiky Vysoké školy báňské-Technické univerzity Ostrava 2;  Národní onkologický registr MOÚ, Brno 3
Published in: Prakt Gyn 2006; 10(4): 136-141

Overview

Objective:
Definition of ovarian carcinoma occurance in the examined group of infertile women after treatment by in vitro fertilization (IVF).

Material:
Collection of data containing 12,527 cycles of assisted reproduction in 4,360 females treated during 1982–2004 in the Centre of Assisted Reproduction (CAR) 01 was applied, creating the source database of the study.

Methodics:
Clinical database was compared with database of the National Oncology Register of Czech Republic (NOR CZ) and number of ovarian carcinoma in the suspense file was found out. The results were compared with the reported ovarian carcinoma in the control database of NOR CZ. Statistical significance of the difference between the occurence of malignant neoplasms in the suspense file and controls was evaluated by test statistics χ2 (p-value).

Results:
Occurence of ovarian carcinoma in the suspense file is six times higher than occurence of ovarian carcinoma in controls (p-value = 0.0001). Statistical evaluation of the occurence of ovarian carcinoma compared to occurence of other malignant neoplasms in the suspense file and controls in the Czech population defines a statistically significant difference in the occurence of ovarian carcinoma in the suspense file in contrast to controls by p-value = 0.004, Odds ratio = 3,454, by 95% reliability interval [1,625–6,715].

Conclusion:
The analysis confirms higher occurence of ovarian carcinoma in the examined group in contrast to controls. The problem of ovarian carcinoma risk as a potential effect of infertility treatment by IVF is becoming more and more clinically and socially important. This problem has to be taken into account and effective analysis methods specifying causal relations and risk factors shall be done.

Key words:
infertility – assisted reproduction – ovarian carcinoma


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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