The Effect of Preoperative Administration of Heparin on the Heparin Resistance Development

Authors: V. Brzek 1;  V. Lonský 2;  S. Jiška 3;  J. Kubíček 1;  D. Nováková 1;  P. Valentová 1;  J. Bímová 1;  M. Volt 1
Authors‘ workplace: Kardiochirurgická klinika FN a LF UK Hradec Králové, přednosta: doc. MUDr. Jan Harrer, CSc. 1;  Kardiochirurgická klinika FN UP Olomouc, přednosta: doc. MUDr. Vladimír Lonský, Ph. D. 2;  Chirurgická klinika FN a LF UK Hradec Králové, přednosta: doc. MUDr. Alexander Ferko, CSc. 3
Published in: Rozhl. Chir., 2009, roč. 88, č. 3, s. 103-105.
Category: Monothematic special - Original


Heparin resistance is relatively frequent problem in cardio surgery. We were try to determine real occurrence heparin resistance before operation.

Aim of the study:
Purpose of the project – to find the real frequency of heparin resistance in patients who will undergo a cardio surgical operation. To find out the dependence between the pre-operational application of heparin and the development of heparin resistance.

We recorded pre-operative administration heparin in patients. If the dose of heparin was 5 mg/kg and more then we insert patients to the group heparin resistant.

In our collection was heparin resistance in 203 patients from 624, it was 32,5%. Test agreement relative frequency with 22% was throw out – p < 0.001 – heparin resistance in our group statistically different from 22% – heparin resistance was higher than hypothesis. Heparin before operation was administrate 181 patients, which make to 29%. For administration of heparin was hypothesis of independence thrown (p < 0.001).

Results of our works confirmed statistically significant occurrence of heparin resistance in patients that was administration heparin pre-operative. Heparin resistance occurred against presumption 22% in 32.5% in our group. It is statistic significant difference.

Key words:
heparin resistance – activated clotting time – heparin – extracorporela circulation


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Surgery Orthopaedics Trauma surgery
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