Authors: V. Brzek 1; V. Lonský 2; S. Jiška 3; J. Kubíček 1; D. Nováková 1; P. Valentová 1; J. Bímová 1; M. Volt 1 Authors‘ workplace: Kardiochirurgická klinika FN a LF UK Hradec Králové, přednosta: doc. MUDr. Jan Harrer, CSc. 1; Kardiochirurgická klinika FN UP Olomouc, přednosta: doc. MUDr. Vladimír Lonský, Ph. D. 2; Chirurgická klinika FN a LF UK Hradec Králové, přednosta: doc. MUDr. Alexander Ferko, CSc. 3 Published in: Rozhl. Chir., 2009, roč. 88, č. 3, s. 103-105. Category: Monothematic special - Original
Background: Heparin resistance is relatively frequent problem in cardio surgery. We were try to determine real occurrence heparin resistance before operation.
Aim of the study: Purpose of the project – to find the real frequency of heparin resistance in patients who will undergo a cardio surgical operation. To find out the dependence between the pre-operational application of heparin and the development of heparin resistance.
Methods: We recorded pre-operative administration heparin in patients. If the dose of heparin was 5 mg/kg and more then we insert patients to the group heparin resistant.
Results: In our collection was heparin resistance in 203 patients from 624, it was 32,5%. Test agreement relative frequency with 22% was throw out – p < 0.001 – heparin resistance in our group statistically different from 22% – heparin resistance was higher than hypothesis. Heparin before operation was administrate 181 patients, which make to 29%. For administration of heparin was hypothesis of independence thrown (p < 0.001).
Conclusion: Results of our works confirmed statistically significant occurrence of heparin resistance in patients that was administration heparin pre-operative. Heparin resistance occurred against presumption 22% in 32.5% in our group. It is statistic significant difference.
Key words: heparin resistance – activated clotting time – heparin – extracorporela circulation
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