Lymphatic Malformations of Head and Neck in Children- 10-year Follow-up Results


Authors: M. Majerčíková 1;  R. Staník 1;  D. Poruban 2,3;  I. Šebová 1
Authors‘ workplace: Detská otorinolaryngologická klinika LF UK a NÚDCH, Bratislava 1;  Klinika stomatológie a maxilofaciálnej chirurgie LF UK a OÚSA, Bratislava 2;  Ambulancia zubného lekárstva - StomEst s. r. o, Bratislava 3
Published in: Otorinolaryng. a Foniat. /Prague/, 68, 2019, No. 1, pp. 4-10.
Category: Original Papers

Overview

Introduction: The paper presents results of a 10-year follow-up of pediatric patients with lymphatic malformations (LM) in the region of head and neck.

Methods: In this study, we retrospectively evaluated 23 patients diagnosed with LM in head and neck region on Pediatric ENT Department, Faculty of Medicine, Comenius University Bratislava between years 2005-2016 with focus on epidemiological data, clinical presentation, anatomical localization of LM, therapeutic process, result achieved and postoperative complications.

Results: Majority of LM were first presented as asymptomatic mass in the head and neck region before the age of two years, most frequently located in submandibular and laterocervical region. The paper confirmed the well-known fact that total removal of LM is not achieved after the initial treatment in the majority of cases, whether by surgical resection or sclerotherapy. For complete removal of lesion, repeated treatment options or a combination of surgical treatment and application of sclerosing agents are often required. It is recognized that macrocytic LM responds to treatment better than microcytic and mixed LM as well the fact, that with the higher stage of lesion by de Serres the worst results are achieved by the therapy. The most common postoperative complication was the temporary paresis of marginal mandibular branch of the facial nerve.

Conclusion: Management of patients with LM remains a major challenge for otorhinolaryngologists and remains individual based on many factors, such as clinical manifestations of LM, growth rate, type and extent of lesion, anatomical localization and possibility of deformity or dysfunction.

Keywords:

lymphatic malformations – head and neck region – surgery – sclerotherapy – complications


Sources

1. Alemi, S. A., Rosbe, K. W., Chan, D. K., Meyer, K. A.: Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations. Int. J. Pediatr. Otorhinolaryngol., 79, 2015, s. 2466-2469.

2. Balakrishnan, K., Edwards, T. C., Perlina, J. A.: Functional and symptom impacts of pediatric head and neck lymphatic malformations: developing a patient-derived instrument. Otolaryngol. Head Neck Surg., 147, 2012, s. 925-931.

3. Bouchard, S., Johnson, M. P., Flake, A. W., Howell, L. J., Myers, L. B., Adzick, N. S., Crombleholme, T. M.: The EXIT procedure: Experience and outcome in 31 cases. J. Pediatr. Surg., 37, 2002, s. 418-426.

4. Elluru, G. D., Balakrishnan, K., Padua, H. M.: Lymphatic malformations: diagnosis and management. Seminars in Pediatric Surgery, 23, 2014, s.178-185.

5. Burezq, H., Williamb, B, Chitte, S. A.: Management of cystic hygromas: 30-year experience, J. Craniofac. Surg., 17, 2006, s. 815-818.

6. Edwards, P. D., Rahbar, R., Ferrari, N. F., Burrows, P. E., Mulliken, J. B.: Lymphatic malformation of the lingual base and oral floor. Plast. Reconstr. Surg., 115, 2005, s. 1906-1915.

7. Fliegelman, L. J., Friedland, D., Brandwein, M., Rothschild, M.: Lymphatic malformation: Predictive factors for recurrence. Otolaryngol. Head Neck Surg., 123, 2000, s. 706-710.

8. Forrester, M. B., Mer, R. D.: Descriptive epidemiology of cystic hygroma: Hawaii, 1986 to 1999. South Med. J., 97, 2004, s. 631-636.

9. Giguere, C. M., Bauman, N. M., Smith, R. J. H.: New treatment options for lymphangioma in infants and children. Ann. Otol. Rhinol. Laryngol., 111, 2004, s. 1066-1075.

10. Grasso, D. L., Pelizzo, G., Zoccini, E., Schleef, J.: Lymphangiomas of the head and neck in children. Acta Otorhinolaringol. Ital., 28, 2008, s. 17-20.

11. Hamoir, M., Plouin-Gaudon, I., Rombaux, P., Francois, G., Cornu, A. S., Desater, G., Clapuy, P., Debauche, C., Verellen, G., Beguin, C.: Lymphatic malformations of the head and neck: a retrospective review and support for staging. Head Neck, 23, 2001, s. 326-337.

12. Charabi, B., Bratlau, P., Bille, M., Holmelund, M.: Cystic hygroma of the head and neck- a long term follow-up of 44 cases. Acta Otolaryngol. Suppl., 543, 2000, s. 248-250.

13. Kennedy, T. L., Whitaker, M., Pellitteri, P., Wood, W. E.: Cystic hygroma/ lymphangioma: a rational approach of management. Laryngoskope, 111, 2001, s.1929-1937.

14. Lerat, J., Mounayer, C., Scomparin, A., Orsel, S., Bessede, J. P., Aubrz, K.: Head and neck lymphatic malformation and treatment: Clinical study of 23 cases. European Annals of Otorhinolaryngology, Head and Neck diseases, 2016.

15. Mulliken, J. B., Glowacki, J.: Hemangiomas and vascular malformation in infants and children: A classification based on endothelial characteristics. Plast. Reconstr. Surg., 69, 1982, s. 412.

16. Ogita, S., Tsuto, T., Nakanuta, K., Deguchi, E., Tokowa, K., Iwai, N.: OK-432 therapy for lymphangioma in children: why and how does it works? J. Pediatr. Surg., 31, 1996, s. 477-480.

17. Olímpio, H. E., Bustorff-Silva, J., Oliveira-Filho, A. G., Araujo, K. C.: Cross-sectional study comparing different therapeutic modalities for cystic lymphangiomas in children. Clinics (Sao Paulo), 69, 2014, s. 505-508

18. Oosthuizen, J. C., Burns, P., Russell, J. D.: Lymphatic malformations: A proposed management algorithm. Int. J. Pediatr. Otorhinolaryngol., 74, 2010, s. 398-403.

19. Perlina, J. A., Maniglia, C., Magit, A., Sidhu, M., Manning, S. C., Chen, E. Y.: Clinical and radiographic findings in children with spontaneous lymphatic malformation regression. Otolaryngol. Head Neck Surg., 138, 2008, s. 772-777.

20. Perlina, J. A., Manning, S. C., Tempero, R. M., Cunningham, M. J., Edmonds, J. L. Jr, Hoffer, F. A., Egbert, M. A.: Lymphatic malformations: Review of current treatment. Otolaryngo. Head Neck Surg., 142, 2010, s. 795-803.

21. Robbins, K. T., Clayma, G., Levine, P. A., Medina, J., Sessins, R., Shaha, A., Som, P., Wolf, G. T.: Neck dissection classification update. Otolaryngol. Head Neck Surg., 128, 2002, s. 751-758.

22. Schwarz, D., Dušek, L.: Webový portál LF MU pro multimediální podporu výuky klinických a zdravotnických oborů. Multimediální podpora výuky klinických a zdravotnických oborů [online]. 2011 [cit.2016-10-17]. Dostupné na http://portal.med.muni.cz/

23. Skarsgard, E. D., Chitkara, U., Krane, E. J., Riley, E. T., Halámek, L. P., Dedo, H. H.: The OOPS procedure (operation on placental support): In utero airway management of the fetus with prenatally diagnosed tracheal obstruction. J. Pediatr. Surg., 31, 1996, s. 826-828.

24. Yavuzer, R., Latifoglu, O., Ataoglu, Ö., Çenetoglu, S.: Lymphatic malformation or lymphovenous malformation. Plast. Reconstr. Surg., 104, 1999, s. 1579-1580.

25. Zhou, Q., Zheng, J. W., Mai, H. M., Luo, Q. F., Fan, X. D., Su, L. X., Wang, Y. A., Qin, Z. P.: Treatment guidelines of lymphatic malformations of the head and neck. Oral Oncol., 47, 2011, s.1105-1109.

Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account