Mucosal Malignant Melanoma of the Nasal Cavity

Authors: P. Šurda 1;  M. Tedla 2;  B. Markalous 1;  E. Větrovcová 1;  H. Zahradníková 1;  H. Gabrielová 1;  D. Cempírková 3
Authors‘ workplace: Ušní, nosní a krční oddělení, Nemocnice Jindřichův Hradec, a. s. 1;  Klinika ORL a chirurgie hlavy a krku Univerzity Komenského, Bratislava 2;  Patologicko-anatomické oddělení, Nemocnice Jindřichův Hradec, a. s. 3
Published in: Otorinolaryng. a Foniat. /Prague/, 65, 2016, No. 1, pp. 58-61.
Category: Case Reports


Mucosal malignant melanoma (MMs) of the nasal cavity is an extremely rare malignant tumor with poor prognosis. In this case report, we present 64-years-old patient with MMs of the nasal cavity. Early diagnosis and radical surgical treatment is crucial for following course of this unfavorable disease. Unfortunately, patients often present in the advanced stage of the disease and nonspecific appearance of the tumor facilitates the late diagnosis. Due to its rarity and different biologic behaviour was TNM classification of the MMs accepted in 2009.

mucosal malignant melanoma, nasal cavity, sinonasal carcinoma, epistaxis


1. Batsakis, J. G.: Pathology of tumors of the nasal cavity and paranasal sinuses and neck cancer. W. B. Saunders Co., Philadelphia, 1999, s. 522-539.

2. Batsakis, J. G., Regezi, J. A., Solomon, A. R., Rice, D. H.: The pathology of head and neck tumors: mucosal melanomas. Head Neck Surg., 5, 1982, 4, s. 404-418.

3. Clifton, N., Harrison, L., Bradley, P. J., Jones, N. S.: Malignant melanoma of nasal cavity and paranasal sinuses: report of 24 patients and literature review. J. Laryngol. Otol., 125, 2011, 5, s. 479-485. 

4. Dahlgren, L., Schedvins, K., Kanter-Lewensohn, L., Dalianis, T., Ragnarsson-Olding, B. K.: Human papilloma virus (HPV) is rarely detected in malignant melanomas of sun sheltered mucosal membranes. Acta Oncol., 44, 2005, 7, s. 694-649.

5. Díaz Molina, J. P., Rodrigo Tapia, J. P., Llorente Pendas, J. L.: Sinonasal mucosal melanomas: review of 17 cases. Acta. Otorrinolaringol. Esp., 59, 2008, 10, s. 489-493.

6. Gabriel, H., McArthur G., Sizeland, A., Henderson, M.: Review: mucosal melanoma of the head and neck. Melanoma Research, 21, 2011, s. 257-266.

7. Goldsmith, H. S.: Melanoma: An overview. CA: Cancer J. Clin., 29, 1979, 4, s. 194-215.

8. Gore M. R., Zanation A. M.: Survival in sinonasal melanoma: A Meta-analysis. J. Neurol. Surg. B, 73, 2012, 3, s. 157-162. DOI: 10.1055/s-0032-1301400.

9. Gras-Cabrerizo J. R., León-Vintró X., Tarruella M. M., Sarria G. P., Gonzalez C. B., Montserrat-Gili J. R., Kolanczak K., Massegur-Solench H.: Management of sinonasal mucosal melanomas and comparison of classification staging systems. Am. J. Rhinol. Allergy. 29, 2015, 1, s. 37-40. DOI: 10.2500/ajra.2015.29.4128.

10. Hofbauer, G. F., Böni, R., Simmen. D., Mihic, D., Nestle, F. O., Burg, G., Dummer, R.: Histological, immunological and molecular features of a nasal mucosa primary melanoma associated with nasal melanosis. Melanoma Res., 12, 2002, 1, s. 77-82.

11. Chang, A. E., Karnell, L. H., Menck, H. R.: The National Cancer Data Base report on cutaneous and noncutaneous melanoma. Cancer, 83, 1998, 8, s. 1664-1678.

12. Krengli, M., Jereczek-Fossa, B. A., Kaanders, J. H., Masini, L., Beldi, D., Orecchia, R.: What is the role of radiotherapy in the treatment of mucosal melanoma of the head and neck? Crit. Rev. Oncol. Hematol., 65, 2008, 2, s. 121-128.

13. Lotem, M., Machlenkin, A., Hamburger, T., Nissan, A., Kadouri, L: Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells. Clin. Cancer. Res., 15, 2009, 1, s. 4968-4977.

14. Lund V. J., Chisholm E. J., Howard D. J., Wei W. I.: Sinonasal malignant melanoma: an analysis of 115 cases assessing outcomes of surgery, postoperative radiotherapy and endoscopic resection, Rhinology, 50, 2012, s. 203-210.

15. Maldonado, J. L., Fridlyand, J., Patel, H., Jain, A. N.: Determinants of BRAF mutations in primary melanomas. J. Natl. Cancer. Inst., 95, 2003, 24, s. 1878-1890.

16. Manolidis, S, Donald, P. J.: Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients. Cancor, 80, 1997, s. 1373-1386.

17. McLaughlin, C. C., Wu, X. C., Jemal, A., Martin, H. J.: Incidence of noncutaneous melanomas in the U.S. Cancer, 105, 2005, 5, s. 1000-1007.

18. Moreno, M. A., Roberts, D. B., Kupferman, M. E., De-Monte, F.: Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer, 116, 2010, 9, s. 2215-2223.

19. Nakashima, J. P., Viégas, C. M., Fassizoli, A. L.: Postoperative adjuvant radiation therapy in the treatment of primary head and neck mucosal melanomas. ORL J. Otorhinolaryngol. Relat. Spec., 70, 2008, 4, s. 344-351.

20. Snow, G. B., van der Waal, I.: Mucosal melanomas of the head and neck. Am. Otolaryngol. Clin. North., 19, 1986, 3, s. 537-547.

21. Thompson, L. D., Wieneke, J. A., Miettinen, M.: Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am. J. Surg. Pathol., 27, 2003, 5, s. 594-611.

22. Uehara, T., Matsubara, O., Kasuga, T.: Melanocytes in the nasal cavity and paranasal sinus: Incidence and distribution in Japan. Acta Pathol. Jpn., 37, 1987, 7, s. 1105-1114.

23. Valková, D., Lischkeová, B., Slavíček, A.: Maligní melanom ORL oblasti. Otorinolaryng. a Foniat., 49, 2000, 3, s. 163-168.

24. Wada, H., Nemoto, K.,Ogawa, Y.: A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan. Int. J. Radiat. Oncol.

Audiology Paediatric ENT ENT (Otorhinolaryngology)
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