Histological Investigation of the Temporal Bone in Foetuseswith Trisomy of the 21st Chromosome

Authors: V. Chrobok;  E. Šimáková *;  V. Jüttnerová **
Authors‘ workplace: ORL oddělení, Nemocnice Pardubice, přednosta prof. MUDr. A. Pellant, DrSc. Fingerlandův ústav patologie, Fakultní nemocnice Hradec Králové, přednosta prof. MUDr. I. Šteiner, CSc. *Oddělení genetiky, Fakultní nemocnice Hradec Králové, přednosta MUDr. V. Jü **
Published in: Otorinolaryng. a Foniat. /Prague/, , 1999, No. 3, pp. 165-167.


The authors evaluate histological findings by light microscopy in 17 temporal bonesof foetuses with genetically confirmed Down syndrome (trisomy of the 21st chromosome). In thearea of the external or middle ear changes were diagnosed in five (29 %) temporal bones, in the innerear in three (18 %) temporal bones.As to pathological findings, retardation of development was involved, abnormalities of the ossiclesin the middle ear and of the auditory tube. A very rare finding in one foetus is bilateral Mondinidysplasia of the cochler.Based on the presented investigation and findings in the literature it is not possible to assess typicalchanges of the vestibular organ in patients with Down syndrome. In clinical practice, however, inthese patients possible affection of hearing must be considered.

Key words:
temporal bone, histology, trisomy 21, Down syndrome.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)

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Otorhinolaryngology and Phoniatrics

1999 Issue 3

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