Postoperative recurrence of Crohn’s disease


Authors: Karel Lukáš
Authors‘ workplace: Univerzita Karlova v Praze, 1. lékařská fakulta, IV. interní klinika VFN
Published in: Čas. Lék. čes. 2011; 150: 594-598
Category: Review Articles

Overview

Postoperative recurrence of Crohn’s disease of the bowel is the appearance of objective signs – defined endoscopically, radiologically or pathologically. New lesion can be visualized endoscopically within weeks to months after ileal resection and ileocolonic anastomosis in the neoterminal ileum. Risk factors are smoking, bacterial flora, environmental factors, immune response and genetic variants. Immunomodulators or biological agents are effective in the prophylaxis of postoperative recurrence.

Key words:
Crohn’s disease, recurrence, azathioprin, biological agents.


Sources

1. Cho SM, Cho SW, Regueiro M. Postoperative Management of Crohn Disease. In: Challenges in Inflammatory Bowel Disease. Med Clin N Amer 2010; 94(1): 179–188.

2. Peyrin-Biroulet L, Léman M. Review article: remission rates achievable by current therapies for inflammatory bowel disease. Aliment Pharmacol Ther 2011; 33(8): 870–879.

3. Prantera C, Scribano ML. Which Type of Treatment Is Advisable in the Prevention of Recurrence After Surgery in Crohn’s Disease? Inflamm Bowel Dis 2008; 14 (S2): S277–S278.

4. Valach V, Kábrt J. Lékařský slovník. Praha: SZN 1961; 402.

5. Rutgeerts P. Review article: recurrence of Crohn’s disease after surgery – the need for treatment of new lesions. Aliment Pharmacol Ther 2006; 24(Suppl 3): 29–32.

6. Stange EF, Travis SP, Vermeire S, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: definition and diagnosis. Gut 2006; 55(Suppl 1): i1–i15.

7. Nos P, DomŹnech E. Postoperative Crohn’s disease recurrence: A practical approach. World J Gastroenterol 2008; 14(36): 5540–5548.

8. Sankey EA, Dhillon AP, Anthony A, et al. Early mucosal changes in Crohn’s disease. Gut 1993; 34: 375–381.

9. Yamamoto T. Factors affecting recurrence after surgery for Crohn’s disease. World J Gastroenterol 2005; 11: 3971–3979.

10. Caprilli R, Gassul MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: a special situations. Gut 2006; 55(Suppl 1): i36–i58.

11. Ahmed T, Rieder F, Fiocchi C, Achkar JP. Pathogenesis of postoperative recurrence in Crohn’s disease. Gut 2011; 60(4): 553–562.

12. Lindberg E, Jarnerot G, Huidfeldt B. Smoking in Crohn’s disease: effects on localisation and clinical course. Gut 1992; 33: 779–782.

13. Sutherland LR, Ramcharan S, Bryant H, Fick G. Effect of cigarette smoking on recurrence of Crohn’s disease. Gastroenterology 1990; 98: 1123–1128

14. Breuer-Katschinski BD, Holländer N, Goebell H. Effect of cigarette smoking on the course of Crohn’s disease. Eur J Gastroenterol Hepatol 1996; 8(3): 225–228.

15. Alvarez-Lobos M, Arostegui JI, Sans M, et al. Crohn’s disease patients carrying NOD2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann Surg 2005; 242(5): 693–700.

16. Munoz-Juarez M, Yamamoto T, Wolf BG, et al. Wide-lumen stapled anastomosis vs.conventional end-to-end anastomosis in the treatment of Crohn’s disease. Dis Colon Rectum 2001; 44: 20–25.

17. Rutgeerts P, Geboes K, Peeters M, Hiele M, et al. Effect of faecal stream diversion on recurrence of Crohn’s disease in the neoterminal ileum. Lancet 1991; 338: 771–774.

18. Yamamoto T. Prevention of recurrence after surgery for Crohn’s disease. World J Gastroenterol 2010; 16(43): 5405–5410.

19. Lowney JK, Dietz DW, Birnbaum EH, Kodner IJ, Mutch MG, Fleshman JW. Is there any difference in recurrence rates in laparoscopic ileocolic resection for Crohn’s disease compared with convenctional surgery? Dis Col Rectum 2006; 49: 58–63.

20. D’Haens G, Geboes K, Ponette E, Penninckx F, Rutgeerts P. Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn’s disease. Gastroenterology 1997; 112: 1475–1481.

21. Fazio WW, Marchetti F, Church M, et al. Effects of resection margins on the recurrence of Crohn’s disease in the small bowel. Ann Surg 1996; 224: 563–573.

22. Ferrante M, deHertog G, Hlavaty T, et al. The value of myenteric plexitis to predict early postoperative Crohn’s disease recurrence. Gastroenterology 2006; 130: 1595–1606.

23. Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn’s disease. Gastroenterology 1990; 99: 956–963.

24. Marteau P, Lemann M, Seksip P, et al. Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn’s disease. Gut 2006; 55: 842–847.

25. Williams RG, Wong WD, Rothenberg DA, Goldberg SM. Recurrence of Crohn’s disease after resection. Brit J Surg 1991; 78(1): 10–19.

26. Markowitz J, Grancher K, Kohn N, Lesser M, Daum F. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn’s disease. Gastroenterology 2000; 119: 895–902.

27. D’Haens, Baert F, van Assche G, et al. Early combined immunosupression or conventional management in patients with newly diagnosed Crohn’s disease. Lancet 2008; 371: 660–667.

28. Papi C, Luchetti R, Gili L, Montani S, Koch M, Capurso L. Budesonide in the treatment of Crohn’s disease: a metaanalysis. Aliment Pharmacol Ther 2000; 14: 1419–1428.

29. Hellers G, Löfberg R, Rutgeerts P, et al. Oral budesonide for prevention of recurrence following ileocolonic resection of Crohn’s disease. A one year placebo-controlled study. Gastroenterology 1996; 110: A923.

30. Colombel JF, Rutgeerts P, Malchow H, et al. Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn’s disease. Gut 2001; 49: 42–46.

31. Chermesh I, Tamir A, Reshef R, et al. Failure of Synbiotic 2000 to prevent postoperative recurrence of Crohn’s disease. Dig Dis Sci 2007; 52: 385–389.

32. Camma C, Giunta M, Rosseli M, et al. Mesalamine in the maintenance treatment of Crohn’s disease: a metaanalysis adjusted for confounding variables. Gastroenterology 1997; 113: 1465–1473.

33. Rutgeerts P, Hiele M, Geboes K, et al. Controlled trial of metronidazole treatment for prevention of Crohn’s disease recurrence after ileal resection. Gastroenterology 1995; 108: 1617–1621.

34. D’Haens, G, Noman M, van Assche G, et al. Severe postoperative recurrence of Crohn’s disease is significantly reduced with combination therapy metronidazole + azathioprine. J Crohn Colitis (Suppl) 2007; 1: 4.

35. Cunningham MF, Docherty NG, Coffey JC, Burke JP, O’Connel PR. Postsurgical recurrence of ileal Crohn’s disease: An update on risk factors and intervention points to a central role for impaired host-microflora homeostasis. World Journal of Surgery 2010; 34(7): 1615–1626.

36. Papay P, Reinisch W, Miehsler W, et al. Maintenance therapy with azathioprine/6-mercaptopurine in Crohn’s disease reduces the risk of re-operation particulary in smokers. J Crohns Colitis (Suppl) 2008; 2: 3.

37. Aberra FN, Lewis JD, Hass D, Rombeau JL, Osborne B, Lichtenstein GR. Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients. Gastroenterology 2003; 125(2): 320–327.

38. Dignass A, Van Assche G, Lindsay JO, et al. European Crohn’s and Colitis Organisation (ECCO). The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management. J Crohns Colitis 2010; 4(1): 28–62.

39. Zachos M, Tondeur M, Griffiths AM. Enteral nutrition therapy for induction of remission of Crohn’s disease. Cochrane Database Syst Rev 2007; 1: CD000542.

40. Renna S, Orlando A, Orlando R, Cottone M. Problems related to postoperative clinical relapse and endoscopic recurrence in Crohn’s disease. Recenti Prog Med 2009; 100(10): 469–478.

41. Saag KG, Teng GG,1 Patkar NM, et al. American College of Rheumatology 2008: Recommendations for the Use of Nonbiologic and Biologic Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis. Arthritis & Rheumatism (Arthritis Care & Research) 2008; 59(6): 762–784.

42. Pearson DC, May GR, Fick G, Sutherland LR. Azathioprine for maintenance of remission in Crohn’s disease. Cochrane Database Rev 2000; 2: CD000067.

43. Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541–1549.

44. Sandborn WJ, Hanauer SB, Rutgeerts P, et al. Adalimumab for maintenance treatment of Crohn’s disease: results of the CLASSIC II trial. Gut 2007; 56: 1232–1239.

45. Doherty G, Bennett G, Patil S, Cheifetz A, Moss AC. Interventions for prevention of postoperative recurrence of Crohn’s disease. Cochrane Database Syst Rev 2009; CD006873.

46. Regueiro M. Management and Prevention of Postoperative Crohn’s Disease. Inflamm Bowel Dis 2009; 15: 1583–1590.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management fenix.admin.empty
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account