Adipose tissue blood flow and metabolic syndrome
Authors:
Richard Sotorník
Authors‘ workplace:
Univerzita Karlova v Praze, 3. lékařská fakulta, II. interní klinika FNKV
Published in:
Čas. Lék. čes. 2010; 149: 155-159
Category:
Review Article
Overview
Worldwide growth of obesity and prevalence of type 2 diabetes mellitus reach the extent of a pandemy and represent a considerable medical and economic problem. An attention devoted to adipose tissue has led to the shift in general perception of its importance. It becomes evident that adipose tissue is not by far only an energy store with thermal and mechanical protection of other organs and body. A number of important functions in intermediary metabolism and hormonal interactions with other tissues have been disclosed. Metabolic flexibility of adipose tissue represents an essential protection against undesirable effects of excessive energy intake. Nevertheless, after exceeding of its physiological capacity adipose tissue becomes an important cause of insulin resistance, oxidative stress and a number of other derangements leading to atherosclerosis progression and increase of cardiovascular morbidity and mortality. Not only adipocytes but also stromal cells and vascular bed participate in the physiological and pathological functions of adipose tissue. Adequate regulation of adipose tissue blood flow ensures communication with other systems and appropriate reactions to energy needs of the organism. Disturbances in adipose tissue blood flow evolve at early stages of obesity and participate in the worsening of metabolic syndrome.
Key words:
adipose tissue blood flow, obesity, type 2 diabetes mellitus, insulin, insulin resistance.
Sources
1. Yach D, Stuckler S, Brownell D. Epidemiological and economic consequences of the global epidemics of obesity and diabetes. Nat Med 2006; 12: 62–66.
2. James W, Jackson-Leach R, Mhurchu CN, Kalamara E, Shayeghi M, Rigby NJ, Nishida C, Rodgers A. Overweight and obesity (high body mass index). In: Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Risk Factors. Genev: World Health Org 2003; 497–596.
3. Arsenault BJ, Pibarot P, Després JP. The quest for the optimal assessment of global cardiovascular risk: are traditional risk factors and metabolic syndrome partners in crime? Cardiology 2009; 113(1): 35–49.
4. Kelley DE, Tahaete EL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 2000; 278: E941–E948.
5. Quisth V, Enoksson S, Blaak E, Hagström-Toft E, Arner P, Bolinder J. Major differences in noradrenaline action on lipolysis and blood flow rates in skeletal muscle and adipose tissue in vivo. Diabetologia 2005; 48(5): 946–953.
6. Hagström-Toft E, Bolinder J, Ungerstedt U, Arner P. A circadian rhythm in lipid mobilization which is altered in IDDM. Diabetologia 1997; 40(9): 1070–1078.
7. Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LK, Frayn KN. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 2002; 51(8): 2467–2473.
8. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002; 45(9): 1201–1210.
9. Samra JS, Simpson EJ, Clark ML, Forster CD, Humphreys SM, Macdonald IA, Frayn KN. Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. Am J Physiol 1996; 271(5): E834–E839.
10. Summers LK, Callow J, Samra JS, Macdonald IA, Matthews DR, Frayn KN. The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat. Int J Obes Relat Metab Disord 2001; 25(9): 1294–1299.
11. Karpe F, Fielding BA, Ilic V, Humphreys SM, Frayn KN. Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis. Int J Obes Relat Metab Disord 2002; 26(1): 1–5.
12. Mather K, Anderson TJ, Verma S. Insulin action in the vasculature: physiology and pathophysiology. J Vasc Res 2001; 38(5): 415–422.
13. Karpe F, Fielding BA, Ardilouze JL, Ilic V, Macdonald IA, Frayn KN. Effects of insulin on adipose tissue blood flow in man. J Physiol. 2002; 540(Pt 3): 1087–1093.
14. Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation 2004; 109(1): 47–52.
15. Stallknecht B, Lorentsen J, Enevoldsen LH, Bülow J, Biering-SŅrensen F, Galbo H, Kjaer M. Role of the sympathoadrenergic system in adipose tissue metabolism during exercise in humans. J Physiol 2001; 536: 283–294.
16. Goossens GH, McQuaid SE, Dennis AL, van Baak MA, Blaak EE, Frayn KN, Saris WH, Karpe F. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J Physiol. 2006; 571: 451–460.
17. Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med 2009; 150(11): 776–783.
18. Galitzky J, Lafontan M, Nordenström J, Arner P. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 1993; 91(5): 1997–2003.
19. Galitzky J, SengenŹs C, Thalamas C, Marques MA, Senard JM, Lafontan M, Berlan M. The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men. J Lipid Res 2001; 42(4): 536–544.
20. Dimitriadis G, Lambadiari V, Mitrou P, Maratou E, Boutati E, Panagiotakos DB, Economopoulos T, Raptis SA. Impaired postprandial blood flow in adipose tissue may be an early marker of insulin resistance in type 2 diabetes. Diabetes Care 2007; 30(12): 3128–3130.
21. Tan GD, Neville MJ, Liverani E, Humphreys SM, Currie JM, Dennis L, Fielding BA, Karpe F. The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank. Diabetologia 2006; 49(1): 158–168.
22. Perez-Matute P, Neville MJ, Tan GD, Frayn KN, Karpe F. Transcriptional control of human adipose tissue blood flow. Obesity (Silver Spring) 2009; 17(4): 681–688.
23. Jansson PA, Larsson A, Lönnroth PN. Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1998; 28(10): 813–818.
24. Summers LK, Samra JS, Humphreys SM, Morris RJ, Frayn KN. Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clin Sci (Lond) 1996; 91(6): 679–683.
25. Jansson PA. Endothelial dysfunction in insulin resistance and type 2 diabetes. J Intern Med 2007; 262(2): 173–183.
26. Thorand B, Baumert J, Chambless L, Meisinger C, Kolb H, Döring A, Löwel H, Koenig W; MONICA/KORA Study Group. Elevated markers of endothelial dysfunction predict type 2 diabetes mellitus in middle-aged men and women from the general population. Arterioscler Thromb Vasc Biol 2006; 26(2): 398–405.
27. Karpe F, Tan GD. Adipose tissue function in the insulin-resistance syndrome. Biochem Soc Trans 2005; 33(5): 1045–1048.
28. Goodfriend TL, Ball DL, Egan BM, Campbell WB, Nithipatikom K. Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension 2004; 43(2): 358–363.
29. Harte A, McTernan P, Chetty R, Coppack S, Katz J, Smith S, Kumar S. Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone. Circulation 2005; 111(15): 1954–1961.
30. Goossens GH, Jocken JW, Blaak EE, Schiffers PM, Saris WH, van Baak MA. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-adrenergic stimulation. Hypertension 2007; 49(3): 542–547.
31. Thatcher S, Yiannikouris F, Gupte M, Cassis L. The adipose renin-angiotensin system: role in cardiovascular disease. Mol Cell Endocrinol 2009; 302(2): 111–117.
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