The Occurrence of Malignancies in Former Blood Donors

Authors: J. Kuntscherová
Authors‘ workplace: Všeobecné lékařství, Kamenice nad Lipou
Published in: Čas. Lék. čes. 2008; 147: 117-119
Category: Special Articles


Occurrence of malignancies in the group of 267 former blood donors who donated blood 20 times and more (multiple donors) were compared with those who donated blood 10 times or less. Cohorts were comparable in age, period from the first donation and ratio of blood groups in A, B, 0 system. In the group of multiple donors, 31 (11.6%) persons were listed in the oncological register for 36 malignancies. Among the less frequent donors only 14 persons (5.3%) were listed with 15 malignancies. The difference in malignancy incidence between both groups is highly significant. The difference is significant for the cohorts of men, being not significant for women; probably because of small number of cases. Our results indicate the possibility of carcinogenic effect of the blood donation.

Key words:
blood donation, malignancy.


1. Janetzko, K., Bocher, R., Klotz, K. P. et al.: Blood donation after reaching 65 years of age. Beitr. Infusionsther. Transfusionsmed., 1996, 33, s. 76–80.

2. Smith, K. J., James, D. S., Hunt, W. C. et al.: A randomized, dobleblindcomparison of donor tolerance of 400 mL, 200 mL and sham red cen donation. Transfusion., 1996, 36, s. 674–680.

3. Fogh-Andersen, N., Altura, B. M., Altura, B. T., Siggaard-Andersen, O.: Changes in plasma ionized calcium and magnesium in blood donors after donation 450 mL blood. Effects of hemodilution and Donnan equilibrium. Scand. J. Clin. Lab. Invest. 1996, 224 (Suppl.), s. 245–250.

4. Furuta, M., Shimizu, T., Mizuno, S. et al.: Clinical evaluation of repeat apheresis in Japan. Vox Sang., 1999, 77, s. 17–23.

5. Hatina, J.: Imunologie nádorů – současný stav a poznatky z 1. mezinárodní konference základní a klinické imunogenetiky. Část 1.– Interakce nádoru a imunitního systému. Klin. onkologie, 2005, 4, s. 119–125.

6. Rejthar, A., Vojtěšek, B.: Obecná patologie nádorového růstu. Praha, Grada Publishing, 2002, s. 208.

7. Merk, K., Mattson, B., Matlson, A. et al.: The incidence of cancer among blood donors. lnt. J. Epidemiol. 1990, 19, s. 505–509.

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management fenix.admin.empty
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account