Study of the Genetic Causes of Polygenetically Determined Endocrinopathies – Patience Can Bring Success
Authors:
B. Bendlová; M. Vaňková; P. Lukášová; J. Včelák; D. Vejražková; M. Kunešová; J. Vrbíková; K. Zajíčková; I. Žofková; K. Vondra; V. Hainer
Authors‘ workplace:
Endokrinologický ústav, Praha
Published in:
Čas. Lék. čes. 2007; 146: 198-204
Category:
Review Article
Overview
Complex endocrinopathies, such as diabetes mellitus, obesity, polycystic ovary syndrome and osteoporosis belong to the most common diseases but their pathogenesis is still not fully explained. Environmental fadors along with genetic factors contribute to their occurrence and development. The study of genetic background is based on different strategies, mostly on linkage analysis and candidate gene approach. The common forms of these endocrinopathies do not seem to be the result of a defect of one or several major genes but the search for complex gene-gene, gene-environment interactions is needed. The article gives a short review of the recent knowledge together with our own experience in the field of study of the genetic background of polygenic diseases.
Key words:
genetics, diabetes mellitus type 2, obesity, polycystic ovary syndrome, osteoporosis, association study, candidate gene, linkage analysis.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
Most read in this issue
- Neurosteroids and Their Function
- Relationships Between the „Eating Inventory“ Factors, Socioeconomic Status, Anthropometric Body Adiposity Indexes and Health Risks in Czech Population
- Obesity Based on Mutation of Genes Involved in Energy Balance
- Growth Hormone Treatment in the Institute of Endocrinology