Regulatory Network of Transcription Factors: Their Key Role in the Development and Function of Pancreas

Czech version

Authors: P. Lukášová; J. Včelák; M. Vaňková; D. Vejražková; B. Bendlová
Authors‘ workplace: Endokrinologický ústav, Praha
Published in: Čas. Lék. čes. 2007; 146: 227-234
Category: Review Article

Overview

Recent molecular biological studies of the pancreatic development have shed new light on the cause of MODY and diabetes mellitus type 2. The identification of transcription factors participating in the regulatory networks cooperating in the development and in adult exocrine and endocrine pancreas enabled the better understanding of the genetic background and subsequent phenotypic features of diabetes.

Key words:
transcription factor, pancreas, mutation, polymorphism, MODY, diabetes mellitus type 2, insulin.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management

The Polycystic Ovary Syndrome and Its Male Equivalent

Polyglandular Activation of Autoimmunity as a Manifestation of Subclinical Endocrinopathies

Evaluation of Results of Iodine Prophylaxis in Czech Republic

Diabetes Mellitus in Adult Patients with Type 1 Diabetes Shows Immunological, Functional and Clinical Differences Depending on the Presence of Autoimmune Thyroiditis

Endocrine Orbitopathy and Significance of Autoantibodies Against 1D Protein

Influence of Early Postnatal Nutrition in Preterm Infants on Their Anthropometric and Hormonal Characteristics at the Age of 10 Years

Relationships Between the „Eating Inventory“ Factors, Socioeconomic Status, Anthropometric Body Adiposity Indexes and Health Risks in Czech Population

Levels of Hormones in Plasma and in Synovial Fluid of Knee Joint of Patients with Rheumatoid Arthritis

The Institute of Endocrinology Celebrates its 50th Anniversary. How is the Institute Poised for the Next 50 Years?

Half Century of the Continuation of the Institute of Endocrinology in Prague

History, Presence and Trends of Steroid Endocrinology

Study of the Genetic Causes of Polygenetically Determined Endocrinopathies – Patience Can Bring Success