Novel Genetic Approaches to the Resolutionof Complex Diseases

Overview

Up to very recent times, genetics as been the science of monogenic disorders based on Mendelian laws. Completion of human genome sequencing as well as that of other species, including mainly the mouše and rat are now providing the opportunity to resolve complex diseases, i.e., those based on several genes and significantly modified by the environment. This complex paradigm, however, requires novel strategies. We propose an integrated use of experimental genetic animal models, with that of relatively isolated human populations with large families and accessible genealogical data. Foreseeably, genetics will be part of this novel medicíně in which the prediction of diseases will be based on individual genomic makeup.

Key words:
genetics of cardiovascular disease, complex diseases, experimental genetics, human genetics