Proteasome inhibitors -⁠ New Option in the Treatment of Tumor Diseases

Czech version

Authors: I. Špička; P. Klener
Authors‘ workplace: /. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 2004; : 701-704
Category:

Overview

Chemotherapy itself probably will not substantially improve the prognosis of cancer patients in the future. Thereforenew methods are needed -⁠ one of the promising option is the direct interference with intracellular metabolism -⁠ „thetargeted therapy". Proteasome inhibitors are the example of this new approach and bortezomib is the first agent inthis class, which enters clinical trials. We summarize theoretical background and the first clinical experiences withthis drug

Key words:
proteasome, ubiquitin, bortezomib, multiple myeloma

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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Article was published in

Journal of Czech Physicians

2004 Issue 10

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