Vitamin D in relation to head and neck cancer

Authors: David Kalfeřt 1;  Marie Ludvíková 2;  Martin Pešta 2;  Ondřej Topolčan 3
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF UK a FN Hradec Králové, přednosta prof. MUDr. Viktor Chrobok, CSc., Ph. D. 1;  Ústav biologie LF UK Plzeň, vedoucí RNDr. Martin Pešta, Ph. D. 2;  Laboratoř imunochemické diagnostiky, oddělení nukleární medicíny LF UK a FN Plzeň, vedoucí prof. MUDr. Ondřej Topolčan, DrSc. 3
Published in: Vnitř Lék 2014; 60(1): 51-58
Category: Reviews


Vitamin D was lately introduced as the important anti-cancer agent with therapeutic potential to be used in prevention and therapy of malignant tumors. Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Prognosis of this cancer is in most patients poor. In attempts to improve therapy of this cancer, contemporary research is focused on extension of the etiological and pathobiological aspects of cancerogenesis of HNSCC. This fact provoked us to summarize present scientific knowledge about etiopathological, chemopreventive and therapeutic role of vitamin D in head and neck squamous cancer and outline the direction of further research in this interesting and from clinical point of view important field.

Key words:
head and neck squamous cell carcinoma – anti-tumor effect – vitamin D


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