The emerging pathogenesis-based strategies for treating sepsis

Authors: Lenka Ledvinová;  Vojtěch Danihel;  Martin Matějovič
Authors‘ workplace: I. interní klinika LF UK a FN Plzeň, přednosta prof. MUDr. Martin Matějovič, Ph. D. ;  Biomedicínské centrum LF UK, Plzeň
Published in: Vnitř Lék 2014; 60(1): 68-72
Category: Reviews


The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the pathogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high. However, the development of adjunctive anti-sepsis therapies has been challenging, with more than 30 unsuccessful drug trials. Fortunately, recent advances in our understanding of the sepsis pathophysiology revealed new pathogenic paradigms, and, thus, provided new exciting therapeutic concepts. In this review, we briefly discuss emerging pathogenesis-based strategies for treating severe sepsis and septic shock.

Key words:
extracorporeal purification methods – immunosuppression – pathogenesis – sepsis – sepsis treatment


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