The impact of a 14- day regular physical exercise regime on the concentration of the classes and sub‑classes of lipoprotein particles in young subjects with a sedentary lifestyle

Authors: P. Sabaka 1;  A. Dukát 1;  S. Oravec 1;  L. Mistríková 2;  D. Baláž 1;  M. Bendžala 1;  Ľ. Gašpar 1
Authors‘ workplace: II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednosta doc. MU Dr. Ľudovít Gašpar, CSc. 1;  Východoslovenský ústav srdcovo‑ cievnych chorôb, a. s., Košice, Slovenská republika, predseda predstavenstva MU Dr. František Sabol, PhD. 2
Published in: Vnitř Lék 2013; 59(10): 880-886
Category: Original Contributions


Recommendations from the cardiological professional companies working in the area of primary prevention of cardiovascular diseases put an emphasis on regular aerobic physical activity. Its positive effect on both cardiovascular and overall mortality has repea­tedly been proven by the observations of prospective and cross‑ sectional epidemiological studies. One of the possible explanations of this positive effect is a change in the concentration of lipoprotein classes and their sub‑classes, which is expressed as a change in their average size. In a group of young healthy men and women with a sedentary lifestyle we observed the effect of medium intensive physical exercise in the form of a 30- minute slow run per day lasting for 14 days. The concentration of lipoprotein classes and sub‑classes were determined through the method of a linear electrophoresis in polyacrylamide gel. In the observed group we found a statistically significant decrease of VLDL, large IDL particles, medium sized LDL, small dense LDL, and medium sized HDL particles. In the light of current knowledge all these lipoprotein particles are deemed as atherogenic. Thus, as little as 14 days of regular exercising has a positive effect on the concentration of plasmatic lipoproteins, and emphasises the role of regular physical activity in the primary prevention of cardiovascular diseases.

Key words:
physical activity –  lipoproteins –  primary prevention


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Diabetology Endocrinology Internal medicine
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