The impact of a 14- day regular physical exercise regime on the concentration of the classes and sub‑classes of lipoprotein particles in young subjects with a sedentary lifestyle


Authors: P. Sabaka 1;  A. Dukát 1;  S. Oravec 1;  L. Mistríková 2;  D. Baláž 1;  M. Bendžala 1;  Ľ. Gašpar 1
Authors‘ workplace: II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednosta doc. MU Dr. Ľudovít Gašpar, CSc. 1;  Východoslovenský ústav srdcovo‑ cievnych chorôb, a. s., Košice, Slovenská republika, predseda predstavenstva MU Dr. František Sabol, PhD. 2
Published in: Vnitř Lék 2013; 59(10): 880-886
Category: Original Contributions

Overview

Recommendations from the cardiological professional companies working in the area of primary prevention of cardiovascular diseases put an emphasis on regular aerobic physical activity. Its positive effect on both cardiovascular and overall mortality has repea­tedly been proven by the observations of prospective and cross‑ sectional epidemiological studies. One of the possible explanations of this positive effect is a change in the concentration of lipoprotein classes and their sub‑classes, which is expressed as a change in their average size. In a group of young healthy men and women with a sedentary lifestyle we observed the effect of medium intensive physical exercise in the form of a 30- minute slow run per day lasting for 14 days. The concentration of lipoprotein classes and sub‑classes were determined through the method of a linear electrophoresis in polyacrylamide gel. In the observed group we found a statistically significant decrease of VLDL, large IDL particles, medium sized LDL, small dense LDL, and medium sized HDL particles. In the light of current knowledge all these lipoprotein particles are deemed as atherogenic. Thus, as little as 14 days of regular exercising has a positive effect on the concentration of plasmatic lipoproteins, and emphasises the role of regular physical activity in the primary prevention of cardiovascular diseases.

Key words:
physical activity –  lipoproteins –  primary prevention


Sources

1. Sans S, Kesteloot H, Kromhout D. On behalf of the Task Force. The burden of cardiovascular diseases mortality in Europe. Task force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 1997; 18: 1231– 1248.

2. Pate RR, Pratt MP, Blair SN et al. Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995; 273: 402– 407.

3. Paffenbarger RS Jr, Hyde RT, Wing AL et al. Physical activity, all‑cause mortality, and longevity of college alumni. N Engl J Med 1986; 314: 605– 613.

4. Blair S, Kohl HI, Barlow C et al. A prospective study of healthy and unhealthy men. JAMA 1995; 273: 1093– 1098.

5. Svačinová H, Mrkvicová V, Pochmonová J et al. Kombinovaný trénink u mužů s metabolickým syndromem po akutní koronární příhodě. Vnitř Lék 2011; 57: 764– 771.

6. Jakes RW, Day NE, Khaw KT et al. Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC‑ Norfolk population‑based study. Eur J Clin Nutr 2003; 57: 1089– 1096.

7. Češka R, Vráblík M, Sucharda P. Dyslipidémie a obezita 2011. Jak spolu souvisejí a v čem se liší. Vnitř Lék 2011; 57: 248– 253.

8. Hambrecht R, Wolf A, Gielen S et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454– 460.

9. Hasbum B, Real JT, Sánchez C et al. Effects of a controlled program of moderate physical exercise on insulin sensitivity in nonobese, nondiabetic subjects. Clin J Sport Med 2006; 16: 46– 50.

10. Kodama S, Tanaka S, Saito K et al. Effect of aerobic exercise training on serum levels of high‑density lipoprotein cholesterol: a meta‑analysis. Arch Intern Med 2007; 167: 999– 1008.

11. Varady KA, Bhutani S, Klempel MC et al. Lipids Health Dis. Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults. Lipids Health Dis 2011; 10: 119.

12. Kraus WE, Houmard JA, Duscha BD et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002; 347: 1483– 1492.

13. Alam S, Stolinski M, Pentecost C et al. The effect of a six‑ month exercise program on very low‑ density lipoprotein apolipoprotein B secretion in type 2 diabetes. J Clin Endocrinol Metab 2004; 89: 688– 694.

14. Couillard C, Despres JP, Lamarche B et al. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Arterioscler Thromb Vasc Biol 2001; 21: 1226– 1232.

15. Leon AS, Rice T, Mandel S et al. Blood lipid response to 20 weeks of supervised exercise in a large biracial population: the HERITAGE Family Study. Metabolism 2000; 49: 513– 520.

16. Goliasch G, Oravec S, Blessberger H et al. Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (≤ 40 years of age). Eur J Clin Invest 2012; 42: 631– 636.

17. Austin MA, Breslow JL, Hennekens CH et al. Low‑ density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988; 260: 1917– 1921.

18. Oravec S, Dukát A, Gavorník P et al. Lipoproteínový profil séra pri novozistenej artériovej hypertenzii. Úloha aterogénnych lipoproteínov v patogenéze ochorenia. Vnitř Lék 2010; 56: 967– 971.

19. Vasankari TJ, Kujala UM, Vasankari TM et al. Reduced oxidized LDL levels after a 10- month exercise program. Med Sci Sports Exerc 1999; 30: 1496– 1501.

20. Vasankari TJ, Kujala UM, Vasankari TM et al. Reduced oxidized LDL levels after a 10- month exercise program. Med Sci Sports Exerc 1998; 30: 1496– 1501.

21. Nordestgaard BG, Tybjaerg‑ Hansen A. IDL, VLDL, chylomicrons and atherosclerosis. Eur J Epidemiol 1992; 8 (Suppl 1): 92– 98.

22. Maeno Y, Kashiwagi A, Nishio Y et al. IDL can stimulate atherogenic gene expression in cultured human vascular endothelial cells. Diabetes Res Clin Pract 2000; 48: 127– 138.

23. Kugiyama K, Doi H, Takazoe K et al. Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease. Circulation 1999; 99: 2858– 2860.

24. Johansson J, Carlson LA, Landou C et al. High density lipoproteins and coronary atherosclerosis. A strong inverse relation with the largest particles is confined to normotriglyceridemic patients. Arterioscler Thromb 1991; 11: 174– 182.

25. Leon AS, Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc 2001; 33: 502– 515.

26. Halle M, Berg A, Garwers U et al. Influence of 4 weeks‘ intervention by exercise and diet on low‑ density lipoprotein subfractions in obese men with type 2 diabetes. Metabolism 1999; 48: 641– 644.

27. Nikkila EA, Taskinen MR, Rehunen S et al. Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: relation to serum lipoproteins. Metabolism 1978; 27: 1661– 1671.

28. Packard C, Caslake M, Shepherd J. The role of small, dense low density lipoprotein (LDL): a new look. Int J Cardiol 2000; 74: 17– 22.

29. Wooten JS, Biggerstaff KD, Ben- Ezra V. Responses of LDL and HDL particle size and distribution to omega- 3 fatty acid supplementation and aerobic exercise. J Appl Physiol 2009; 107: 794– 800.

Labels
Diabetology Endocrinology Internal medicine
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account