Prolactine response to stress in patients with systemic lupus erythematodes (SLE), rheumatoid arthritis (RA) and in healthy controls

Authors: C. Dostál 1;  M. Fojtíková 1;  Z. Lacinová 2;  M. Černá 3;  L. Moszkorzová 1;  J. Zvárová 4;  J. Marek 2
Authors‘ workplace: Revmatologický ústav Praha, ředitel prof. MUDr. Karel Pavelka, DrSc. 1;  III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA 2;  Oddělení buněčné a molekulární biologie 3. lékařské fakulty UK Praha, přednosta doc. RNDr. Jan Kovář, DrSc. 3;  EuroMISE Centrum Praha, ředitelka prof. RNDr. Jana Zvárová, DrSc. 4
Published in: Vnitř Lék 2007; 53(12): 1265-1268
Category: Original Contributions


Prolactin is a one of the stress hormones, like the growth hormone, ACTH, cortisol and catecholamins. Among its wide range of functions is the important role of controlling the immune response which is, unlike in the case of cortisol, of stimulatory nature. For this activity, it is monitored as a factor influencing the progress and course of autoimmune diseases. The authors of the paper monitored prolactin response to stress in a normal stress situation, i.e. blood collection. A significant difference was detected between the levels of prolactin in 3 successive blood collections in 30 minute intervals (P < 0.001). Prolactin responded by a prompt increase in the serum level, followed by a relatively fast linear decrease. There was no difference in the response between the SLE and RA patient groups and the healthy population. Therefore we conclude that this is a normal reaction of the organism because acute response to stress in patients with autoimmune diseases is the same as in healthy persons.

prolactin – stress – systemic lupus erythematodes – rheumatoid arthritis


1 .Gala RR. Prolactin and growth hormone in the regulation of the immune system. Proc Soc Exp Biol Med 1991; 198: 513-527.

2. Peeva E, Michael D, Cleary J et al. Prolactin modulates the naive B cell repertoire. J Clin Invest 2003; 111: 275-283.

3. Grimaldi CM. Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells. Curr Opin Rheumatol 2006; 18: 456-461.

4. Ben-Jonathan N, Mershon JL, Allen DL et al. Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr Rev 1996; 17: 639-669.

5. Sabharwal P, Glaser R, Lafuse W et al. Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation. Proc Natl Acad Sci USA 1992; 89: 7713-7716.

6. Schwartz J. Intrapituitary interactions: another level of endocrine regulation. Clin Exp Pharmacol Physiol 2001; 28: 237-238.

7. Kanyicska B, Sellix MT, Freeman ME. Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle. Endocrine 2003; 20: 53-58.

8. Kopecek M, Bares M, Horacek J et al. Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia. Neuro Endocrinol Lett 2006; 27: 803-806.

9. Malý R, Masopust J, Konupcíková K. Prevention of venous thromboembolism in psychiatry. Vnitř Lék 2006; 52(Suppl 1): 73-78.

10. Neidhart M, Gay RE, Gay S. Prolactin and prolactin-like polypeptides in rheumatoid arthritis. Biomed Pharmacother 1999; 53: 218-222.

11. Leanos-Miranda A, Cardenas-Mondragon G. Serum free prolactin concentrations in patients with systemic lupus erythematosus are associated with lupus activity. Rheumatology (Oxford) 2006; 45: 97-101.

12. Kozáková D, Rovenský J, Cebecauer L et al. Prolactin levels and autoantibodies in female patients with systemic lupus erythematosus. Z Rheumatol 2000; 59(Suppl 2): 80-84.

13. Rovenský J, Bakosová J, Payer J et al. Increased demand for steroid therapy in hyperprolactinemic patients with rheumatoid arthritis. Int J Tissue React 2001; 23: 145-149.

14. Imrich R, Rovensky J, Cervenakova Z et al. Hyperprolactinemia does not influence hypothalamic-pituitary-adrenocortical function during hypoglycemia in women. Int J Tissue React 2002; 24: 73-78.

15. Imrich R, Tibenska E, Koska J et al. Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8+ cells in vivo. Neuroimmunomodulation 2004; 11: 133-140.

16. Rovensky J, Kvetnansky R, Radikova Z et al. Hormone concentrations in synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol 2005; 23: 292-296.

17. Rovensky J, Imrich R, Radikova Z et al. Peptide hormones and histamine in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis. Endocr Regul 2005; 39: 1-6.

18. Rovensky J, Simorova E, Radikova Z et al. Comparison of hormone transfer to pleural and synovial exudates. Endocr Regul 2006; 40: 29-36.

19. Moszkorzová L, Lacinová Z, Marek J et al. Hyperprolactinaemia in patients with systemic lupus erythematosus. Clin Exp Rheumatol 2002; 20: 807-812.

20. Dostál C, Marek J, Moszkorzová L et al. Effects of stress on serum prolactin levels in patients with systemic lupus erythematosus. Ann N Y Acad Sci 2002; 966: 247-251.

21. Dostál C, Moszkorzová L, Musilová L et al. Serum prolactin stress values in patients with systemic lupus erythematosus. Ann Rheum Dis 2003; 62: 487-488.

22. Pohorecky LA, Baumann MH, Benjamin D. Effects of chronic social stress on neuroendocrine responsiveness to challenge with ethanol, dexamethasone and corticotropin-releasing hormone. Neuroendocrinology 2004; 80: 332-342.

23. Low D, Purvis A, Reilly T et al. The prolactin responses to active and passive heating in man. Exp Physiol 2005; 90: 909-917.

24. Tomei F, Ciarrocca M, Cherubini E et al. Prolactin levels in workers exposed to chemical, physical and psycho-social urban stressors. J Occup Health 2006; 48: 253-260.

25. Low D, Cable T, Purvis A. Exercise thermoregulation and hyperprolactinaemia. Ergonomics 2005; 48: 1547-1557.

26. Saez Mdel C, Barriga C, Garcia JJ et al. Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin. Mol Cell Biochem 2007; 294: 19-24.

27. Eijsbouts AM, van den Hoogen FH, Laan RF et al. Decreased prolactin response to hypoglycaemia in patients with rheumatoid arthritis: correlation with disease activity. Ann Rheum Dis 2005; 64: 433-437.

28. Chikanza IC, Petrou P, Chrousos G et al. Excessive and dysregulated secretion of prolactin in rheumatoid arthritis: immunopathogenetic and therapeutic implications. Br J Rheumatol 1993; 32: 445-448.

29. Templ E, Koeller M, Riedl M et al. Anterior pituitary function in patients with newly diagnosed rheumatoid arthritis. Br J Rheumatol 1996; 35: 350-356.

30. Gutiérrez MA, Garcia ME, Rodriguez JA et al. Hypothalamic-pituitary-adrenal axis function in patients with active rheumatoid arthritis: a controlled study using insulin hypoglycaemia stress test and prolactin stimulation. J Rheumatol 1999; 26: 277-281.

Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue 12

2007 Issue 12

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account