Tumor lysis syndrome

Authors: A. Kafková ;  E. Tóthová
Authors‘ workplace: Klinika hematológie a onkohematológie Lekárskej fakulty UPJŠ a FNsP Košice, Slovenská republika, prednosta prof. MUDr. E. Tóthová, CSc.
Published in: Vnitř Lék 2005; 51(2): 216-220
Category: Reviews


Tumor lysis syndrome with hypeuricemia, also known as TLS, is a potentially serious complication of cancer chemotherapy and it can result in life–threatening complications such as renal failure and cardiac arrhythmias. The aim of this paper is to provide a general overview of the pathophysiology and corresponding signs and symptoms of TLS and review clinical and laboratory monitoring parameters. An understanding of the pathophysiology of TLS and meticulous assessment of signs and symptoms and monitoring of the laboratory data, as well as early recognition of problems are essential for optimal patient outcomes. Both allopurinol and rasburicase offer flexibility in the management of TLS and may allow for further avoidance of the consequences of inadequate management of this syndrome.

Key words:
tumor lysis syndrome – chemotherapy – pathophysiology – treatment – prevention


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