Chondroprotectives and their effect on the cartilage properties

Authors: J. Rychlíčková
Authors‘ workplace: Oddělení klinické farmacie, Ústavní lékárna, Masarykův onkologický ústav, Brno ;  Farmakologický ústav LF, Kamenice, Brno
Published in: Geriatrie a Gerontologie 2018, 7, č. 4: 167-169
Category: Review Article


The current therapy of osteoarthritis is based on symptomatic pain management and possible use of chondroprotectives. The ideal chondroprotective agent is able to slow down the progressive narrowing of the joint space, to give protection to chondrocytes and to improve biomechanical properties of the cartilage. There are many different agents available, with declared positive influence on the cartilage function. We will focus on two of them, glucosamine and chondroitin, which the most marketed products are based on. The basic pharmacology properties, quality limits of clinical trials and aspects of rational use of these drugs in clinical practice will be discussed.


chondroprotectives – glucosamine sulphate – chondroitin sulphate – osteoarthritis treatment


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Geriatrics General practitioner for adults Orthopaedic prosthetics
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