Regulation of transient lower esophageal sphincter relaxation in the pathogenesis of gastroesophageal reflux disease

Authors: M. Ďuriček;  M. Schnierer
Authors‘ workplace: Interná klinika gastroenterologická JLF UK a UN Martin, Slovenská republika
Published in: Gastroent Hepatol 2016; 70(4): 305-309
Category: Clinical and Experimental Gastroenterology: Review Article
doi: 10.14735/amgh2016csgh.info09


Transient lower esophageal sphincter relaxation (TLESR) is a reflexive process allowing swallowed air to be released from the stomach. At the same time, it is also one of the mechanisms participating in the emergence of gastroesophageal reflux. TLESR regulation in humans has been well studied, but there is little information so far on the influence of esophageal stimuli on TLESR development. If TLESR regulation by esophageal stimulation exists, then it is likley to be mediated by afferent esophageal neurons, whose stimulation by refluxate components (e. g. acid) can lead to TLESR dysregulation. The authors are contemplating, within the context of recently published work, the importance of TLESR dysregulation in the pathogenesis of gastroesophageal reflux disease.

Key words:
gastroesophageal reflux – esophagus – transient lower esophageal sphincter relaxation – acid

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

19. 8. 2015

10. 11. 2015


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