Vedolizumab in the therapy of ulcerative colitis patients

Authors: M. Lukáš
Authors‘ workplace: Klinické a výzkumné centrum pro idiopatické střevní záněty ISCARE I. V. F. a.  s. a 1. LF UK v Praze
Published in: Gastroent Hepatol 2015; 69(1): 29-32
Category: IBD: Review Article
doi: 10.14735/amgh201529


Vedolizumab is a monoclonal IgG1 antibody, which has been approved to use in clinical practice for ulcerative colitis patients in Europan Union a few months ago. There is a big expectation on availability of vedolizumab at the market in Czech Republic in these year. The clinical research named GEMINI I proved that vedolizumab is a very effective drug in patients with moderate to severe ulcerative colitis. The significant advantages of vedolizumab therapy is a high efficacy in those patients who failed to anti‑TNFα therapy, sustained response due to maintenance therapy with arising effect over time, a minimal drug’s immunogenicity and highly safety drug’s profile, which is caused by a high selectivity for gastrointestinal tract. There are some disadvantages or uncertainty which include slow antiinflammatory therapeutic response, restricted effect on extraintestinal manifestations.

Key words:
vedolizumab – ulcerative colitis –  bio­logical therapy

Autor deklaruje, že v souvislosti s předmětem studie nemá žádné komerční zájmy.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

12. 1. 2015

9. 2. 2015


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Paediatric gastroenterology Gastroenterology and hepatology Surgery

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