Immunoablative therapy and autologous hematopoietic stem cell transplantation in a patient with aggressive Crohn’s disease refractory to medical therapy

Authors: V. Hrubá 1;  T. Kozák 2;  D. Ďuricová 1,3;  J. Novák 2;  Š. Rahmatová 4;  N. Machková 1;  M. Bortlík 1,5;  M. Lukáš Jr 1;  K. Mitrová 1,6;  M. Horák 7;  M. Lukáš 1,8
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a.  s., Praha 1;  Interní hematologická klinika, 3. LF UK a FN Královské Vinohrady, Praha, PRVOUK Praha 2;  Ústav farmakologie, 1. LF UK, Praha 3;  Ústav hematologie a krevní transfuze, Praha 4;  Interní klinika 1. LF UK a ÚVN, Praha 5;  Pediatrická klinika 2. LF UK a FN v Motole, Praha 6;  Radiodia­gnostické oddělení, Nemocnice Na Homolce, Praha 7;  Ústav lékařské bio­chemie a laboratorní dia­gnostiky, 1. LF UK, Praha 8
Published in: Gastroent Hepatol 2015; 69(1): 50-54
Category: IBD: Case Report
doi: 10.14735/amgh201550


Despite the progress in the treatment of Crohn’s disease (CD), there are still patients with refractory to medical therapy, including immunosuppressants and biologicals. Recently, a new immunoablative therapy with autologous hematopoietic stem cell transplantation (ASCT) has been proposed for the management of intractable forms. The article reports the case of the first pa­tient with refractory CD who underwent ASCT in the Czech Republic. The patient, a 37-year-old man, after four intestinal resections with continuous disease activity despite intensive anti-inflammatory therapy, was treated with ASCT from May to July 2014 at the Department of Internal Medicine and Hematology, University Hospital Královské Vinohrady.

Key words:
Crohn’s disease –  autologous hematopoietic stem cell transplantation

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

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1. Hasselblatt P, Drognitz K, Potthoff K et al. Remission of refractory Crohn‘s disease by high‑dose cyclophosphamide and autologous peripheral blood stem cell transplantation. Aliment Pharmacol Ther 2012; 36(8): 725– 735. doi: 10.1111/ apt.12032.

2. Al‑ Toma A, Nijeboer P, Bouma G et al.Hematopoietic stem cell transplantation for non‑malignant gastrointestinal diseases. World J Gastroenterol 2014; 20(46): 17368– 17375. doi: 10.3748/ wjg.v20.i46. 17368.

3. Hommes DW, Duijvestein M, Zelinkova Zet al. Long‑term follow‑up of autologous hematopoietic stem cell transplantation for severe refractory Crohn‘s disease. J Crohns Colitis 2011; 5(6): 543– 549. doi: 10.1016/ j.crohns.2011.05.004.

4. Burt RK, Craig RM, Milanetti F et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti‑TNF refractory Crohn disease: long‑term follow‑up. Blood 2010; 116(26): 6123– 6132. doi: 10.1182/ blood‑ 2010‑ 06‑ 292391.

5. Oyama Y, Craig RM, Traynor AE et al. Autologous hematopoietic stem cell trans­plantation in patients with refractory Crohn’s disease. Gastroenterology 2005; 128(3): 552– 563.

6. Daikeler T, Labopin M, Di Gioia M et al. Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: a retrospective study of the EBMT Autoimmune Disease Working Party. Blood 2011; 118(6): 1693– 1698. doi: 10.1182/ blood‑ 2011‑ 02‑ 336156.

7. Cassinotti A, Annaloro C, Ardizzone S et al.Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn‘s disease. Gut 2008; 57(2): 211– 217.

8. Clerici M, Cassinotti A, Onida F et al. Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn‘s disease. Dig Liver Dis 2011; 43(12): 946– 952. doi: 10.1016/ j.dld.2011.07.021.

9. Hawkey C, Allez M, Ardizzone S et al. OC‑ 014 clinical and endoscopic improvement following hemopoietic stem cell transplantation vs mobilisation alone in Crohn’s disease. Gut 2013; 62 (Suppl 1): A6.

Paediatric gastroenterology Gastroenterology and hepatology Surgery

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