Immunoablative therapy and autologous hematopoietic stem cell transplantation in a patient with aggressive Crohn’s disease refractory to medical therapy


Authors: V. Hrubá 1;  T. Kozák 2;  D. Ďuricová 1,3;  J. Novák 2;  Š. Rahmatová 4;  N. Machková 1;  M. Bortlík 1,5;  M. Lukáš Jr 1;  K. Mitrová 1,6;  M. Horák 7;  M. Lukáš 1,8
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty ISCARE I. V. F. a.  s., Praha 1;  Interní hematologická klinika, 3. LF UK a FN Královské Vinohrady, Praha, PRVOUK Praha 2;  Ústav farmakologie, 1. LF UK, Praha 3;  Ústav hematologie a krevní transfuze, Praha 4;  Interní klinika 1. LF UK a ÚVN, Praha 5;  Pediatrická klinika 2. LF UK a FN v Motole, Praha 6;  Radiodia­gnostické oddělení, Nemocnice Na Homolce, Praha 7;  Ústav lékařské bio­chemie a laboratorní dia­gnostiky, 1. LF UK, Praha 8
Published in: Gastroent Hepatol 2015; 69(1): 50-54
Category: IBD: Case Report
doi: 10.14735/amgh201550

Overview

Despite the progress in the treatment of Crohn’s disease (CD), there are still patients with refractory to medical therapy, including immunosuppressants and biologicals. Recently, a new immunoablative therapy with autologous hematopoietic stem cell transplantation (ASCT) has been proposed for the management of intractable forms. The article reports the case of the first pa­tient with refractory CD who underwent ASCT in the Czech Republic. The patient, a 37-year-old man, after four intestinal resections with continuous disease activity despite intensive anti-inflammatory therapy, was treated with ASCT from May to July 2014 at the Department of Internal Medicine and Hematology, University Hospital Královské Vinohrady.

Key words:
Crohn’s disease –  autologous hematopoietic stem cell transplantation

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
5. 1. 2015

Accepted:
2. 2. 2015


Sources

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Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery

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