Obesity as a risk factor in atrial fibrillation and heart failure

Authors: Jakub Jurica;  Martin Jozef Péč;  Jakub Benko;  Tomáš Bolek;  Matej Samoš;  Peter Galajda;  Marián Mokáň
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2021; 10(3): 180-186


The prevalence of obesity in the world population is rising at an alarming rate and it is evident now that obesity is a worldwide pandemic with a significant impact on the morbidity and mortality of the world population. It is a wellknown fact that obesity is closely associated with cardiovascular disease. It is also considered as a risk factor of various diseases including atrial fibrillation (AF) and chronic heart failure (HF). Multiple recent studies point to obesity being a potential causal factor in the development of AF and HF. The discussion about obesity in relation to cardiovascular disease cannot omit the so-called obesity paradox, which represents a dilemma for clinicians around the world and is still a source of irregularities regarding the strategy of weight reduction in obese patients with HF. Most recently, the obesity paradox is also assumed to play a role in the association between obesity and the thromboembolic complications of AF. The aim of this article is to provide an insight into the role of obesity not only as a risk factor, but also as a possible etiologic agent of AF and HF, to elucidate the pathological mechanisms of the AF and HF development on the basis of obesity and to describe treatment options in the light of novel evidence.


obesity – atrial fibrillation – chronic heart failure


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