DAPA-CKD Study results in the context of preceding studies with gliflozins in the relation to chronic kidney disease
Authors:
Ivan Tkáč
Authors‘ workplace:
Excelentný tím pre výskum aterosklerózy (EXTASY), LF UPJŠ v Košiciach
Published in:
Forum Diab 2021; 10(3): 218-221
Category:
Overview
The studies of cardiovascular safety studies with gliflozins have not only shown a benefit in reducing cardiovascular disease based mainly on their beneficial effect on heart failure, but have also suggested a possible benefit in preventing the progression of chronic kidney disease in patients with type 2 diabetes. As renal outcomes were monitored as a secondary outcome in these studies, it was necessary to conduct studies directly targeting patients with chronic kidney disease. The first such study with canagliflozin confirmed the benefit of this agent in preventing the progression of chronic kidney disease in patients with diabetic nephropathy. The aim of the DAPA-CKD study, which tested dapagliflozin, was not only to confirm the effect of gliflozin in patients with chronic kidney disease in diabetes, but also to observe whether this effect would also be present in subjects without diabetes The study showed that additive treatment with dapagliflozin led to a 29/1 000 patient-years (PR) reduction in the primary composite outcome and a 9/1 000 PR reduction in overall mortality. The effect was similar in both patients with type 2 diabetes and non-diabetic nephropathy. In addition, treatment with gliflozins has an additive effect to treatment with renin-angiotensin system inhibitors, which to date has been the only evidence-based treatment in preventing the progression of chronic kidney disease.
Keywords:
type 2 diabetes – chronic kidney disease – DAPA-CKD study – dapagliflozin –SGLT2 inhibitors
Sources
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Diabetology Endocrinology Internal medicineArticle was published in
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