Oral semaglutide: the future of GLP1 receptor agonism?


Authors: Matej Samoš;  Marián Mokáň
Authors‘ workplace: I. interná klinika JLF UK a UNM, Martin
Published in: Forum Diab 2021; 10(3): 213-217
Category:

Overview

Semaglutide is a modern anti-diabetic agent acting as a glucagon like peptide 1 receptor agonist (GLP-1 RA). GLP-1 RA therapy improves glycemic control, significantly reduces body weight, and improves blood pressure control and blood lipid levels, together with low risk of hypoglycemia. Moreover, this therapy protects against atherogenesis and has a proven cardiovascular and nephroprotective benefit and a protective effect on pancreatic B-cells function. According to current recommendations, GLP-1 RA therapy should be preferred in diabetic patients with high cardiovascular risk or with already existing atherosclerotic cardiovascular disease; nevertheless, this recommendations could not be fully adopted due to a need for drug subcutaneous application. Oral semaglutide is the first oral GLP-1 RA with real possibility of clinical use. This article summarizes the current knowledge about oral semaglutide, about its effect on glycemic control and data regarding its cardiovascular safety from currently available clinical trials.

Keywords:

compliance – type 2 diabetes mellitus – GLP1 receptor agonists – oral semaglutide


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Labels
Diabetology Endocrinology Internal medicine
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