Pathophysiological aspects of diabetic foot syndrome

Authors: B. Krahulec 1,2;  L. Štrbová 1,2
Authors‘ workplace: II. interná klinika Lekárskej fakulty Univerzity Komenského a Univerzitná nemocnica Bratislava, Nemocnica Staré Mesto, prednosta doc. MUDr. Ľudovít Gašpar, CSc. 1;  Katedra diabetológie, porúch látkovej premeny a výživy Lekárskej fakulty Slovenskej zdravotníckej univerzity, Bratislava, vedúci katedry doc. MUDr. Boris Krahulec, CSc. 2
Published in: Forum Diab 2013; 2(2): 84-89


Diabetic foot syndrome is a serious complication of the underlying disease diabetes mellitus. It is defined as ulceration or destruction of tissues distal to the ankle complicated under adverse circumstances with infection or gangrene and lead to undesirable limb amputation. In etiopathogenesis is present neuropathy, as the main factor almost in each case and limb ischemia. A very important factor is deformity of the foot, based on arthropathy, cheiroartropathy or changes on the amputation stump. Considerable are changes affecting microcirculation as well. Biomechanical stress and trauma are also significant, often underestimated adverse factors in daily practice. It is important to search vulnerable diabetic foot in daily practice and educate patients or their relatives.

Key words:
diabetic foot syndrome – etiopathogenesis – risk factors


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Diabetology Endocrinology Internal medicine
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