Fecal bacteriotherapy for the treatment of recurrent Clostridium difficile colitis used in the Clinic of Infectious Diseases of the University Hospital Brno in 2010–2014 – a prospective study
Authors:
P. Polák 1,2,3; M. Freibergerová 1; P. Husa 1,2; J. Juránková 3,4; R. Svačinka 2; L. Mikešová 2; H. Kocourková 2; M. Mihalčin 1,2; R. Skalická 2; R. Stebel 1,2; M. Porubčanová 1,2
Authors‘ workplace:
Lékařská fakulta Masarykovy univerzity Brno
1; Klinika infekčních chorob, Fakultní nemocnice Brno
2; Oddělení klinické hematologie, Fakultní nemocnice Brno
3; Oddělení klinické mikrobiologie, Fakultní nemocnice Brno
4; Katedra laboratorních metod, Lékařská fakulta Masarykovy univerzity Brno
5
Published in:
Epidemiol. Mikrobiol. Imunol. 64, 2015, č. 4, s. 232-235
Category:
Original Papers
Overview
Introduction:
The aim of the study is to assess the efficacy of fecal bacteriotherapy in the treatment of Clostridium difficile colitis.
Materials and methods:
A prospective study of fecal bacteriotherapy in 80 adult patients hospitalized in the Clinic of Infectious Diseases, University Hospital Brno between 1 January 2010 and 31 December 2014.
Results:
During the study period, 80 patients were treated with fecal bacteriotherapy. The majority of the study group received fecal bacteriotherapy via a nasojejunal tube (n=78) and two patients via a rectal enema. Six patients were instilled with 20 g of feces, with a success rate of 50 %. The outcomes of nine patients were unevaluable. In the rest of 65 patients, the success rate with 40 g of feces was 83.1 %. There were no severe adverse events or mortality associated with fecal bacteriotherapy.
Conclusions:
Fecal bacteriotherapy is a safe and effective treatment modality in Clostridium difficile colitis.
Keywords:
Clostridium difficile colitis – recurrence – fecal bacteriotherapy
Sources
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Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
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