Prevalence of Anti-Epstein-Barr Virus Antibodies in Children and Adolescents with Secondary Immunodeficiency

Authors: A. Bučková
Authors‘ workplace: Analyticko-diagnostické laboratórium, s. r. o. Prešov, Slovenská republika
Published in: Epidemiol. Mikrobiol. Imunol. 59, 2010, č. 3, s. 133-137


Secondary immunodeficiency can be caused by multiple factors. We studied whether there is a relationship between secondary immunodeficiency and Epstein-Barr virus (EBV) infection in children and adolescents. The study group included 845 patients with common variable immunodeficiency aged from 2 to 18 years and 394 age-matched healthy controls. IgM and IgG antibodies against viral capsid antigen (VCA) and IgG antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1) were quantitated by an enzyme-linked immunosorbent assay. A statistically significant difference (p = 0.004) in the prevalence of EBV infection was found between the immunodeficient children and controls, both aged 2 to 6 years. The statistically significant difference was confirmed in boys (p = 0.003), but not in girls of this age group.

Key words:
secondary immunodeficiency – Epstein-Barr virus – children – adolescents.


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