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Tuberculous spondylitis or Pott’s disease – a relic of the past?


Authors: Bača Uboš 1;  Magner Martin 2;  Martinů Vendula 3;  Doležalová Karolína 1
Authors‘ workplace: Pediatrická klinika, 1. LF UK, a Fakultní Thomayerova, nemocnice, Praha 1;  Klinika pediatrie a dědičných, poruch metabolismu, 1. LF UK, a VFN, Praha 2;  Pediatrická klinika, 2. LF UK, a FN Motol, Praha 3
Published in: Čes-slov Pediat 2023; 78 (1): 20-25.
Category:
doi: https://doi.org/10.55095/CSPediatrie2023/003

Overview

Tuberculosis (TB) is a disease caused by a group of bacteria, collectively named the M. tuberculosis complex. In most cases, tuberculosis in children affects the lungs (80%) but can affect any other organ (extrapulmonary tuberculosis). Although the Czech Republic is a country with a low incidence of tuberculosis (< 5 cases per 100 000 population per year),(1) severe and rare forms of extrapulmonary tuberculosis occur.

This case report presents a one-year-old girl with coincident pulmonary and two extrapulmonary forms of tuberculosis (spine and brain). The patient due to persistent X-ray opacification underwent other diagnostic examinations verifying lung tuberculosis. The surprising finding was thoracic spondylitis with abscess and tuberculomas in the CNS. We achieved good clinical progresswith antituberculosis treatment, spine surgery intervention, and a multidisciplinary approach.

Keywords:

tuberculosis – extrapulmonary tuberculosis – osteoarticular tuberculosis – Pott’s disease – basilar meningitis – tuberculoma


Sources

1. Ústav zdravotnických informací a statistiky České republiky. Základní přehled epidemiologické situace ve výskytu tuberkulózy v České republice v roce 2020. Dostupné na: http://www.uzis.cz/res/f/008358/tbc2020-cz. pdf

2. Starke RJ, Donald PR. Handbook of Child and Adolescent Tuberculosis. 1st ed. Oxford University Press 2016.

3. WHO. Global tuberculosis report 2021. Dostupné na: https://www.who. int/publications/i/item/9789240037021

4. Pohunek P, Koťátko P, Tuková M (eds). Dětská pneumologie. In: Doležalová K, et al. Tuberkulóza a mykobakteriózy v dětském věku. Praha: Mladá fronta 2018: 359.

5. Doležalová K. Aktuální problémy dětské tuberkulózy. Pediatrie pro praxi 2019; 20(3): 152–156.

6. Santiago-Garcia B, Blázquez-Gamero D, Baquero-Artigao F, et al. Pediatric extrapulmonary tuberculosis: Clinical spectrum, risk factors and diagnostic challenges in a low prevalence region. Pediatr Infect Dis J 2016; 35(11): 1175–1181.

7. Cruz AT , Starke JR. Pediatric tuberculosis. Pediatrics in review 2010; 31(1): 13–26.

8. Shah I, Dani S, Shetty NS, et. al. Profile of osteoarticular tuberculosis in children. Indian J Tuberc 2020; 67(1): 43–45.

9. González Saldaña N, Macías Parra M, Xochihua Díaz L, et al. A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center. BMC Pulm Med 2021; 21(1): 265.

10. Agarwal A. Paediatric osteoarticular tuberculosis. J Clin Orthop Trauma 2020; 11: 202–207.

11. WHO. WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents. 2022. Dostupné na: https:// www.who.int/publications/i/item/9789240046764

12. Garg RK, Somvanshi DS. Spinal tuberculosis: A review. J Spinal Cord Med 2011; 34(5): 440–452.

13. Ross JA. Percivall Pott 1714–1788. Paraplegia 1986; 24(5): 287–292.

14. Cambau E, Drancourt M. Steps towards the discovery of Mycobacterium tuberculosis by Robert Koch, 1882 [online]. Clin Microbiol Infect 2014; 20(3): 196–201.

15. WHO. WHO global lists of high burden countries for tuberculosis (TB), TB/ HIV and multidrug/rifampicin-resistant TB (MDR/RR-TB), 2021-2025. Dostupné na: https://cdn.who.int/media/docs/default-source/hq-tuberculosis/ who_globalhbcliststb_2021-2025_backgrounddocument.pdf?sfvrsn=- f6b854c2_9

16. Dhamnetiya D, Patel P, Jha RP, et al. Trends in incidence and mortality of tuberculosis in India over past three decades: a joinpoint and age–period– cohort analysis. BMC Pulm Med 2021; 21(1): 375

17. Chatterjee S, Banta A. The spectrum of tuberculosis of the spine in pediatric age group: a review. Childs Nerv Syst 2018; 34: 1937–1945.

18. Kilborn T, Janse van Rensburg P, Candy S. Pediatric and adult spinal tuberculosis: imaging and pathophysiology. Neuroimaging Clin N Am 2015; 25 (2): 291–231.

19. Bousetta R, Zairi M, Sami SB, et al. Torticollis as a sign of spinal tuberculosis. Pan Afr Med J 2020; 36 (277): 1–5.

20. Agarwal A, Bhat MS, Kumar A, et al. Lymphocyte/monocyte ratio inosteoarticular tuberculosis in children: a haematological biomarker revisited. Trop Doct 2016; 46(2), 73–77.

21. Kunju P, James J. Central nervous system tuberculosis in children. Pediatr Inf Dis 2019; 1(1): 23–29.

22. Čábelová T, Dedek V, Kabíček P, et al. Tuberkulózní meningitidy v České republice – konfrontace s diagnózou po 20 letech. Čes-slov Pediat 2016; 71(7–8): 345–350.

23. Chatterjee S. Brain tuberculomas, tubercular meningitis, and post-tubercular hydrocephalus in children. J Pediatr Neurosci 2011; 6 (Suppl 1): 96– S100.

24. Kheir AEM, Ibrahim SA, Hamed AA, et al. Brain tuberculoma, an unusual cause of stroke in a child with trisomy 21: A case report. J Med Case Rep 2017; 11(1): 114.

25. Pospíšilová D, Blatný J, členové Pracovní skupiny dětské hematologie ČR. Referenční meze krevního obrazu (KO), retikulocytů (RET), normoblastů (NRBC) a diferenciálního rozpočtu leukocytů (DIF) u dětí. 2018. Dostupné na: https://labsekce.hematology.cz/wp-content/uploads/2021/08/Doporuceni_ LS_CHS_CLS_JEP-Ref_meze_deti-KO_Diff_Ret_NRBC_v03.pdf

Labels
Neonatology Paediatrics General practitioner for children and adolescents
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