Intrauterine Growth Retardation and Fetal Origin of Diseases at the Adult Age

Authors: J. Kytnarová 1;  B. Zlatohlávková 3;  M. Fedorová 3;  G. Malošková 3;  M. Kršek 2
Authors‘ workplace: Klinika dětského a dorostového lékařství VFN a UK 1. LF, Praha přednosta prof. MUDr. J. Zeman, DrSc. 1;  III. interní klinika VFN a UK 1. LF, Praha přednosta prof. MUDr. Š. Svačina, DrSc., MBA 2;  Gynekologicko-porodnická klinika VFN a UK 1. LF, Praha přednosta prof. MUDr. A. Martan, DrSc. 3
Published in: Čes-slov Pediat 2008; 63 (6): 320-326.
Category: Review


The reasons for fetal growth restriction are heterogeneous. It was postulated that low birthweight together with postnatal environmental factors might increase the risk for number of diseases in adulthood, i.e. hypertension, ischaemic heart disease or diabetes mellitus type 2. Pathophysiology of this relationship is not fully understood, but it is evident, that pre- and postnatal growth and subsequent risks are modulated by different metabolic changes and genetic factors. According to programming hypothesis intrauterine adaptation to disadvantageous influences leads to long-term metabolic and endocrine alterations. IGF-I, IGF-II and their binding proteins (IGFBP) system as well as certain polymorphisms in IGF-I promotor gene might be possible candidates in explaining the link between intrauterine growth retardation and some of the diseases in adulthood.

Key words:
intrauterine growth retardation, low birthweight, IGF-I, IGF-II, IGF binding proteins, IGF-I gene polymorphism


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Neonatology Paediatrics General practitioner for children and adolescents
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