Authors: L. Elbl 1; H. Hrstková 2; V. Chaloupka 1; J. Novotný 3 Authors‘ workplace: Oddělení funkčního vyšetřování Fakultní nemocnice Brno, pracoviště Bohunice1 přednosta doc. MUDr. V. Chaloupka, CSc. I. dětská interní klinika Fakultní nemocnice Brno, pracoviště Dětská nemocnice2 přednostka doc. MUDr. H. Hrstková, CSc. Fakulta sportovníc Published in: Čes-slov Pediat 2003; (3): 121-128. Category:
Introduction: The objective of the submitted work is to assess by means of echocardiographic examination inpatients in long-term remission after treatment of a malignity during childhood the incidence of altered leftventricular function and express an opinion on the presence of „late cardiotoxicity“.Patients and methods: The authors examined 155 patients who suffered during childhood or adolescence froma malignant disease and were treated by chemotherapy containing anthracyclines. The group comprised 90 boysand 65 girls aged 15 ± 4.9 years (5 - 29, median 15 years). The age at the time of establishment of the diagnosis andbeginning of treatment was 8.6 ± 4.9 years (1 - 18, median 8 years). The mean follow up period of the patients was7.3 ± 4 years (1 - 21, median 6.3 years). All patients achieved remission of the disease. The patients were givena cumulative dose of doxorubicin and possibly also daunorubicin (KD) 250 ± 131 mg/m2 (50 - 1200, median240 mg/m2). The patients were examined by echocardiography at rest. The values of the ejection fraction (EF)
Key words: late cardiotoxicity, anthracycline, echocardiography, child tumours
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