Authors: Ľ. Tichá 1; L. Kovács 1; E. Tomečková 2; A. Gondová 1; J. Birčák 1; M. Benedeková 1 Authors‘ workplace: 1. detská klinika LFUK a DFNsP, Bratislava 1 Published in: Čes-slov Pediat 2000; (5): 296-299. Category:
Leptin is an adipose tissue hormone which is a signal for the regulation of food intake and thus of body weight.Precise mechanisms which regulate leptin levels are not known so far. The objective of the presented work was toinvestigate leptin levels in children with two controversial nutritional disorders - anorexia nervosa and obesity, inrelation to their body mass index.In girls with anorexia nervosa (n = 26, age 15.18 ± 0.45 years, weight deficit 23.96 ± 1.59%), obesity (n = 26, age14.53 ± 0.63 years, overweight 54.94 ± 3.29% as compared with normal for the given age group) blood specimenswere take to examine basal leptin levels. The control group was formed by 15 healthy girls (n = 15, age 14.41 ± 0.52years, body weight 2.77 ± 2.03%). The leptin levels were assessed by the RIA method and compared mutually.The mean leptin values in patients with anorexia nervosa were significantly lower (1.91 ± 0.23 ng/ml) ascompared with healthy children (6.07 ± 0.91 ng/ml, p
Key words: leptin, anorexia nervosa, obesity, body mass indexes
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